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  • D Rose
  • 1977
1. The responses of single units in the cat's primary visual cortex to moving bars have been examined quantitatively as a function of bar length.2. For about half the cells studied, very long bars evoked weaker responses than short bars, implying that there were inhibitory regions flanking the receptive field centre. In another quarter of the cell sample,(More)
The overall pattern of c-fos immunoreactivity was studied in the brainstem and spinal cord of cats subjected to moderate hypoxia or hypercapnia. In control cats (normoxic, normocapnic), c-fos was expressed mainly in pontine and periaqueductal grey but not in brainstem structures engaged in respiratory control nor in the spinal cord. Both hypoxia and(More)
At the rostral level of the thorax, the intercostal muscles participate both in postural and respiratory functions to a variable degree depending upon the considered muscle: external intercostal, intercartilaginous, internal intercostal, and triangularis sterni. In order to determine if these physiological properties are related to a special organization at(More)
1. Intercostal muscles participate both in postural and respiratory functions to a variable degree dependent upon the specific interspace or muscle. In order to determine if these physiological properties are related to a special organization at the spinal cord level, we have used the retrograde transport of HRP as a tool for studying the spinal(More)
The activities of the diaphragmatic, internal intercostal and hypoglossal-innervated muscles were studied in adult decerebrate cats in response to 5-HT and related agents (8-OH-DPAT and DOI). The drugs were placed on the floor of the IVth ventricle. The mean respiratory frequency (Fi) increased (124-193% of the control value) within 3 min of the 5-HT(More)
The role of 5-HT in inducing apnoeas (a major element in sudden infant death syndrome) is controversial because while 5-HT is a respiratory depressant in vivo, it evokes respiratory analeptic effects when applied to the isolated brainstem of the newborn rat. In decerebrate newborn rats, the electrical activity of the diaphragm and that of a hypoglossally(More)
The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy subjects attended on up to 12 occasions.(More)
BACKGROUND For patients with cystic fibrosis (CF)-related partial respiratory insufficiency and reduced arterial oxygen tension at ground level, the mild hypobaric environment on commercial jet aircraft poses the risk of severe hypoxemia. Thus, physicians should be able to estimate the extent of in-flight hypoxia. OBJECTIVES To derive tools for estimating(More)
The intrinsic positive-end-expiratory pressure (PEEPi) increases the inspiratory load, the cost of breathing and thus oxygen consumption (V(O2)). It has been shown that applying an extrinsic positive-end-expiratory pressure (PEEPe) reduces the inspiratory threshold load but the optimal PEEPe level is still in debate. We hypothesize that the best level of(More)