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The authors are members of the ISPD Ad Hoc Advisory Committee on Peritoneal Dialysis Related Infections. P eritonitis remains a leading complication of perito-neal dialysis (PD). Around 18% of the infection-related mortality in PD patients is the result of peritonitis. Although less than 4% of peritonitis episodes result in death, peritonitis is a "(More)
T his current version provides a summary of recommendations for best practice in creating peritoneal access for patients on peritoneal dialysis (PD). A more detailed review of peritoneal access is available in the report from the Renal Association Working Party on Peritoneal Access (final version April 2008) available at www.renal.org. These guidelines are(More)
Transcapillary ultrafiltration during CAPD is determined by the ultrafiltration coefficient of the peritoneal membrane and by Starling forces, the latter being mainly determined by the osmolality of the dialysate. Dialysate sodium concentration decreases during a dwell, implying that: (1) sodium passes the peritoneal membrane to a lesser extent than H2O,(More)
During continuous ambulatory peritoneal dialysis (CAPD) peritoneal vessels are dilated. Nitric oxide (NO) causes vasodilation in many organs. Nitrate, a stable metabolite of NO, was measured in plasma and dialysate. In 6 stable CAPD patients standard peritoneal analyses were performed. The mass transfer area coefficient (MTAC) of nitrate was 11.5 mL/min(More)
BACKGROUND In peritoneal dialysis (PD) total net ultrafiltration (NUF) is dependent on transport through small pores and through water channels in the peritoneum. These channels are impermeable to solutes, and therefore, crystalloid osmotic-induced free water transport occurs through them. Several indirect methods to assess free water transport have been(More)
Patients treated with continuous ambulatory peritoneal dialysis (CAPD) may suffer from recurrent peritonitis episodes caused by Staphylococcus epidermidis. Early recruitment of granulocytes from the peripheral blood is important for the peritoneal antibacterial defense of CAPD patients. In this study, human peritoneal mesothelial cells were shown to produce(More)
A review is given on peritoneal function, especially ultra-filtration and ultrafiltration failure followed by recommendations on how to translate pathophysiology into clinical practice. The subsequent consequences for management of peritoneal membrane function and for patient information are also included.
Peritoneal transport rates and net drained volume are reported to be different for peritoneal dialysis (PD) patients with diabetes mellitus (DM) as compared with patients without DM. The difference has been considered to be caused by exposure to high plasma glucose levels before PD initiation. However, the results of previous studies conflict. Transport of(More)
OBJECTIVE To evaluate the use of low-calcium solution as the standard solution in chronic peritoneal dialysis patients. DESIGN Prospective long-term follow-up study over a one-year period. SETTING University hospital. INTERVENTIONS The change of the calcium concentration of the dialysate from 1.75 mmol/L to 1.25 mmol/L. MAIN OUTCOME MEASURES Serum(More)