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OBJECTIVE Child maltreatment is a problem that has longer recognition in the northern hemisphere and in high-income countries. Recent work has highlighted the nearly universal nature of the problem in other countries but demonstrated the lack of comparability of studies because of the variations in definitions and measures used. The International Society(More)
There is limited data on the efficacy of hydroxyurea (HU) in Indian sickle cell anemia patients who have severe manifestations despite high fetal hemoglobin (Hb F). Sixty sickle cell anemia children (5-18 years) with more than three episodes of vasoocclusive crises or blood transfusions per year were randomized to receive HU (n = 30) or placebo (n = 30)(More)
OBJECTIVE To determine the prevalence of physical violence during pregnancy and the factors associated with it. DESIGN A population-based, multicentre, cross sectional household survey. SETTING Rural, slum and urban non-slum areas of Bhopal, Chennai, Delhi, Lucknow, Nagpur, Trivandrum and Vellore, in India. PARTICIPANTS A total of 9938 women who were(More)
BACKGROUND Although the history of recognition of child abuse in Europe and North America extends over 40 years, recognition and data are lacking in other parts of the world. Cultural differences in child-rearing complicate cross-cultural studies of abuse. OBJECTIVE To ascertain rates of harsh and less-harsh parenting behavior in population-based samples.(More)
OBJECTIVE To develop a child victimization survey among a diverse group of child protection experts and examine the performance of the instrument through a set of international pilot studies. METHODS The initial draft of the instrument was developed after input from scientists and practitioners representing 40 countries. Volunteers from the larger group(More)
There is clinical variability in the presentation of sickle cell disease among Indians. Vaso-occlusive crisis is common among non-tribal patients. Hydroxyurea, induces fetal hemoglobin (HbF) synthesis and reduces the clinical severity of sickle cell disease but individual patients have a variable response. This study was undertaken to investigate the(More)
OBJECTIVE Sickle cell disease has variable clinical manifestations. Activation of neutrophils plays an important role in the initiation and propagation of vaso occlusive crises which can be analysed by determining the expression of neutrophil antigens such as CD16, CD32, and CD62L. The common FcγR polymorphisms (FcγRIIA and FcγRIIIB) are considered to(More)
OBJECTIVES To gain consensus among an ethnically and linguistically diverse group of international child protection experts on the structure and content of a new survey tool for retrospective measurement of child abuse, and to determine the performance of the instrument through an international field trial with young adults. METHODS The questionnaire was(More)
BACKGROUND Sickle cell disease (SCD) is a major health burden in India. The objective of the study was to establish a neonatal screening program and to understand the clinical course of children with SCD in central India. METHODS AND FINDINGS Pregnant mothers were screened for sickle hemoglobin using the solubility test. Babies were screened by high(More)
OBJECTIVES To explore clinical, hematological and molecular features of homozygous sickle cell (SS) disease in central India. METHODS Focusing on the pediatric age group attending a clinic at the Akola Government Medical College, Akola, Maharashtra State, India, a cross-sectional assessment of 91 patients with sickle cell disease was performed during one(More)