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Molecular understanding of the mechanism of excitation-contraction (EC) coupling in skeletal muscle has been made possible by cultured myotube models lacking specific dihy-dropyridine receptor (DHPR) subunits and ryanodine receptor type 1 (RyR1) isoforms. Transient expression of missing cDNAs in mutant myotubes leads to a rapid recovery, within days, of(More)
We present computed spectra, as seen by a distant observer, from the accretion disc around a rapidly rotating neutron star. Our calculations are carried out in a fully general relativistic framework, with exact treatment of rotation. We take into account the Doppler shift, gravitational redshift and light bending effects in order to compute the observed(More)
Apart from few early biophysical studies, the relative thermal instability of HbE has been only shown by clinical investigations. We have compared in vitro thermal stability of HbE with HbA2 and HbA using optical spectroscopy. From absorption measurements in the soret region, synchronous fluorescence spectroscopy and dynamic light scattering experiments, we(More)
Autophagy and the unfolded protein response (UPR) both promote activation of hepatic stellate cells (HSC), however the link between the two stimuli remains unclear. Here we have explored the role of X-box binding protein 1 (XBP1), one of three UPR effector pathways and sought to establish the interdependence between autophagy and the UPR during HSC(More)
The dihydropyridine receptor (DHPR) β1a subunit is essential for skeletal muscle excitation-contraction coupling, but the structural organization of β1a as part of the macromolecular DHPR-ryanodine receptor type I (RyR1) complex is still debatable. We used fluorescence resonance energy transfer (FRET) to probe proximity relationships within the β1a subunit(More)
—Vehicle License Plate Recognition is a very significant & complex area of Image processing which has various applications. In situations where no standard number plate format and font is maintained, identification becomes difficult. But more important task is to identify the characters which is very similar to their structure such as 2-Z, B-8, S-5 etc(More)
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