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Roles of divalent metal ions in flap endonuclease–substrate interactions
Flap endonucleases (FENs) have essential roles in DNA processing. They catalyze exonucleolytic and structure-specific endonucleolytic DNA cleavage reactions. Divalent metal ions are essentialExpand
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A Role for Caspases in Controlling IL-4 Expression in T Cells1
Although caspase activation is critical for T cell proliferation following activation, the role of caspases in T cell differentiation is unclear. In this study, we have examined the effect ofExpand
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Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding
Previous structural studies on native T5 5′ nuclease, a member of the flap endonuclease family of structure-specific nucleases, demonstrated that this enzyme possesses an unusual helical arch mountedExpand
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Low-surfactant microemulsions for enhanced topical delivery of poorly soluble drugs.
PURPOSE To develop and characterize low-surfactant microemulsion (ME) gels to enhance topical delivery of poorly soluble drugs. METHOD Five low surfactant ME formulations were manufacturedExpand
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Unusually wide co-factor tolerance in a metalloenzyme; divalent metal ions modulate endo?exonuclease activity in T5 exonuclease
TLDR
T5 5'-3' exonuclease is a member of a homologous group of 5' nucleases which require divalent metal co-factors to perform endonucleolytic cleavage of single-stranded DNA. Expand
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A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease.
The flap endonucleases, or 5' nucleases, are involved in DNA replication and repair. They possess both 5'-3' exonucleolytic activity and the ability to cleave bifurcated, or branched DNA, in anExpand
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Back bugged: A case of sacral hydatid cyst
Hydatid cyst of bone constitutes only 0.5 - 2% of all hydatidoses. The thoracic spine is the most common site of spinal hydatidoses. Primary hydatid cyst of the sacral spinal canal is rare. AExpand
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Giant cell ependymoma of a cervical spinal cord.
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Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain.
BACKGROUND The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function. Expand
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Malignant prolactinoma: a rare case report.
Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describeExpand
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