Dipak K Hazra

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Molecular biology techniques have identified specific DNA sequences, termed cellular oncogenes, having regulating roles in the control of cell growth. The expression of one such cellular oncogene, c-myc, belonging to the nuclear group of oncogenes has been found to be related to cell proliferation. The distribution of the c-myc, oncogene coded protein p62(More)
Diabetes Mellitus constitutes a major global challenge in this century, and the epidemic particularly afflicts India which has been termed the Diabetes capital of the world. 33 million subjects were afflicted in 2003 and this was projected to reach a figure of 57.2 million in 2025 and 80.9 million by 2030. By 2025 75% of the world’s population would be from(More)
Radiosilver-111 and Radiogold-199 were proposed by us (1) as suitable isotopes for radioimmunotherapy in areas such as India by reason of their suitable half-lives and B-emissions (Ag-111T 1/2=7.45 d and Au-199T 1/2=3.15 d). Since silver is monovalent, it is difficult to link to conventional bifunctional chelates. We therefore explored the use of(More)
A series of copper- and alkaline-earth-metal-based multidimensional metal-organic frameworks, {[CuMg(pdc)2(H2O)4]·2H2O}n (1), [CuCa(pdc)2]n (2), [CuSr(pdc)2(H2O)3]n (3), and {[CuBa(pdc)2(H2O)5]·H2O}n (4), where H2Pdc = pyridine-2,5-dicarboxylic acid, were hydrothermally synthesized and characterized. Two different metals act as the active center to catalyze(More)
Despite attempts to maintain asepsis, good manufacturing practices, and the use of terminal sterilization by millipore filtration, the nuclear practitioner is always worried about the possibility of endotoxin contamination. Methods, such as ion-exchange chromatography, have been tried for removing endotoxins during the preparation of radiolabeled(More)
Earlier studies described the linkage of silver to antibodies using SH groups generated by the reduction of the SS groups using ascorbic acid (1) analogous to the Thakur and DeFulvio technique for linking technetium to antibodies. This work describes the linkage of silver to IgG after introducing SH groups by coupling the IgG to 2-imino thiolane. The(More)
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