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Sporadic medullary thyroid carcinoma (MTC) harbors RET gene somatic mutations in up to 50 % of cases, and RAS family gene mutations occur in about 10 %. A timely and comprehensive characterization of molecular alterations is needed to improve MTC diagnostic stratification and design-tailored therapeutic approaches. Twenty surgically resected sporadic MTCs,(More)
The present study was conducted to evaluate the prevalence of gastrointestinal parasites in dogs with no clinical signs (n=175; group H) and in dogs with gastrointestinal disease (n=193; group D) that were admitted to a veterinary hospital. In group H, the overall prevalence of intestinal parasites (i.e. the presence of at least one species) was 20.6%.(More)
BACKGROUND There is still no widely accepted molecular marker available to distinguish between gastric high-grade intraepithelial neoplasia (HG-IEN) and invasive early gastric cancer (EGC). METHODS HG-IEN and EGC lesions coexisting in the same patient were manually microdissected from a series of 15 gastrectomies for EGC; 40 ng DNA was used for multiplex(More)
This paper presents a framework that allows plugging or unplugging Grid-related features to legacy code. Those features can, for example, transform sequential-like code to a parallel version or even a distributed version. With this approach scientists could develop their code as they are used to, that is, they could spent their time programming as they are(More)
Muscle invasive bladder cancer (MIBC, stage ≥T2) is generally associated with poor prognosis, constituting the second most common cause of death among genitourinary tumours. Due to high molecular heterogeneity significant variations in the natural history and disease outcome have been observed. This has also delayed the introduction of personalized(More)
This paper describes how to improve separation between domain-specific code and parallel code in skeletal systems. Traditionally, the code used to exploit parallelism is tangled among domain-specific code, which leads to problems such as: poor maintainability, lower flexibility, and weak scalability. In this paper we introduce the design of the YaSkel(More)
Within the World Health Organization-International Atomic Energy Agency (WHO-IAEA) collaboration for delivery of technical assistance to its Member States, the National Cancer Control Programme/Plan (NCCP) Core Capacity Self-Assessment Tool has been used to obtain a simple and quick qualitative overview of national cancer control planning and on-going(More)