Dino Levy

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According to the United Nations, approximately 24.7 million people used am-phetamines, 16 million used cocaine, and 12 million used heroin in 2006/07 [Costa, 2008]. Full recovery from drug addiction by chemical treatment and/or social and psychological support is uncertain. The present investigation was undertaken to expand our understanding of the factors(More)
AIMS To evaluate the effect of repeated high-frequency transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC), combined with either smoking or neutral cues, on cigarette consumption, dependence and craving. DESIGN Participants were divided randomly to real and sham stimulation groups. Each group was subdivided randomly(More)
Drug addiction is associated with long-lasting neuronal adaptations including alterations in dopamine and glutamate receptors in the brain reward system. Treatment strategies for cocaine addiction and especially the prevention of craving and relapse are limited, and their effectiveness is still questionable. We hypothesized that repeated stimulation of the(More)
Personalized medicine is rapidly evolving with the objective of providing a patient with medications based on the "use of genetic susceptibility or pharmacogenetic testing to tailor an individual's preventive care or drug therapy" [1]. It is reasonable to foresee that this domain will incorporate sources of biological knowledge other than genetics including(More)
Drug addiction is a worldwide epidemic. To reduce its spread, understanding the nature of addiction is crucial and possible treatments have to be developed. Current models of drug addiction only explain why addiction is overwhelming and cannot be overcome. Instead we focus on the dynamic of addiction, which includes rehabilitation and relapse. The model(More)
Reconsolidation of long-term memory is blocked in animal models by macromolecular synthesis inhibitors, resulting in item-specific post-retrieval amnesia. The induction of such amnesia could ameliorate traumatic memories and phobias. However, this pharmacological approach is of limited value in humans because of toxicity. Here we report that reconsolidation(More)
Use and misuse of addictive substances has been an ongoing phenomenon from early civilizations to the present. Experimental observations endorse the implication of a cognitive component during the addictive course. The present investigation proposes a learning mechanism affecting the cognitive level of a multiscale model of addiction. Simulations account(More)
Relapse is the chief problem of drug addiction where a successfully abstinent patient returns to seemingly extinct manners of drug consumption. While various parameters were identified as affecting relapse, the general dynamics of drug consumption is yet to be understood. We introduce a model that describes addiction focusing on a single state-value factor,(More)
RATIONALE AND OBJECTIVE Relapse to drug use in humans can be induced by exposure to drug-associated cues. The ability of drug cues to provoke 'relapse' has been studied in laboratory animals using a reinstatement model in which resumption of drug seeking is assessed after extinction of drug-reinforced responding. In this model, there are no adverse(More)
Drug addiction is recognized as a disease which affects a significant number of human beings. The United Nations Office on Drugs and Crime estimates that between 15 and 21 million people used opiates at least once in 2007. A novel computational model of drug addiction, which considers the addictive process as non‐monotonic and thereby enables the(More)