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Hormesis can and Does Work in Humans
If we accept the validity of the general concept of physiological hormesis as being the phenomenon of achieving health beneficial effects by exposure to mild stress, then hormesis is being appliedExpand
Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis
Aging is the progressive shrinkage of the homeodynamic space. A crucial component of the homeodynamic space is the stress response (SR), by virtue of which a living system senses disturbance andExpand
Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation
Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecularExpand
Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro
Wound healing becomes impaired in several diseases and during ageing. A commonly used model for the study of wound healing is a scratched monolayer of cells in vitro, which is convenient for theExpand
Basal Level of Autophagy Is Increased in Aging Human Skin Fibroblasts In Vitro, but Not in Old Skin
Intracellular autophagy (AP) is a stress response that is enhanced under conditions of limitation of amino acids, growth factors and other nutrients, and also when macromolecules become damaged,Expand
Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction
Hormesis in aging is represented by stress-induced stimulation of protective mechanisms and strengthened homeostasis/homeodynamics. Since calorie restriction (CR) generally stimulates variousExpand
Hormesis and aging
Mild stress-induced hormetic stimulation of protective mechanisms in cells and organisms can result in potential antiaging effects. Detailed molecular mechanisms that bring about the hormetic effectsExpand
Differential translocation of heat shock factor-1 after mild and severe stress to human skin fibroblasts undergoing aging in vitro
Repeated exposure to mild heat shock (HS) has been shown to induce a wide range of health promoting hormetic effects in various biological systems, including human cells undergoing aging in vitro. InExpand
A preliminary attempt to establish multiple stress response profiles of human skin fibroblasts exposed to mild or severe stress during ageing in vitro
Optimal stress response (SR) is an essential aspect of the property of dynamic homeostasis of all biological systems, including cells in culture. Whereas severe stress can induce the so-calledExpand