Dino A Giussani

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Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep.

Dino A Giussani, James A Spencer, Patricia J. Moore, Laura Bennet, Mark A. Hanson
The Journal of physiology
1993

1. We studied the effects of acute isocapnic hypoxia on arterial and central venous pressures, carotid and femoral blood flows and heart rate in intact and carotid denervated fetal sheep between 118… (More)

Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress

Dino A Giussani, Emily Jane Camm, +11 authors Emilio A. Herrera
PloS one
2012

Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs… (More)

High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep.

Emilio A. Herrera, Victor M Pulgar, +9 authors Aníbal J. Llanos
American journal of physiology. Regulatory…
2007

Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze… (More)

A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep.

Jan B. Derks, Dino A Giussani, +4 authors Peter W Nathanielsz
The Journal of physiology
1997

1. Chronically instrumented, late-gestation fetal sheep were prepared to: (1) characterize cardiovascular, endocrine and behavioural effects of fetal treatment with clinical doses of betamethasone… (More)

The role of oxygen in prenatal growth: studies in the chick embryo.

Dino A Giussani, Carlos E Salinas, M. Arévalo Villena, Carlos E. Blanco
The Journal of physiology
2007

The compelling evidence linking small size at birth with later cardiovascular disease has renewed and amplified scientific and clinical interests into the determinants of fetal growth. It is accepted… (More)

Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level

Emilio A. Herrera, Raquel A. Riquelme, +7 authors Aníbal J. Llanos
American journal of physiology. Regulatory…
2010

We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms… (More)

Low Doses of Dexamethasone Suppress Pituitary-Adrenal Function but Augment the Glycemic Response to Acute Hypoxemia in Fetal Sheep during Late Gestation

Andrew J W Fletcher, Mark R Goodfellow, +4 authors Dino A Giussani
Pediatric Research
2000

Despite the widespread use of antenatal glucocorticoid therapy in obstetric practice, little is known about the effects of synthetic glucocorticoids on the fetal capacity to respond to episodes of… (More)

Endocrine and metabolic programming during intrauterine development.

Abigail L Fowden, Dino A Giussani, Alison J Forhead
Early human development
2005

In humans, low birth weight is associated with an increased risk of metabolic dysfunction in adult life. Many of these metabolic disorders have an endocrine origin and are accompanied by abnormal… (More)

Developmental programming of cardiovascular disease by prenatal hypoxia.

Dino A Giussani, Sandra T Davidge
Journal of developmental origins of health and…
2013

It is now recognized that the quality of the fetal environment during early development is important in programming cardiovascular health and disease in later life. Fetal hypoxia is one of the most… (More)

The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation

Denise S Fernandez-Twinn, Heather L. Blackmore, +4 authors Susan E Ozanne
Endocrinology
2012

Human and animal studies suggest that suboptimal early nutrition during critical developmental periods impacts long-term health. For example, maternal overnutrition during pregnancy and lactation in… (More)

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