Dingzi Zhou

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OBJECTIVE To examine the impact of microRNA-146a (miR-146a) on pulmonary function and disease severity in silicosis patients. METHODS Twenty-nine silicosis patients and six observation subjects were recruited. MiR-146a expression level was detected by qRT-PCR, and pulmonary function was assessed with a spirometer. RESULTS MiR-146a expression level was(More)
Pulmonary fibrosis is prevalent in Paraquat (PQ) poisoning. Transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of Type II alveolar epithelial cells (AT2) contributed to the pulmonary fibrosis in some pulmonary disease. In this study, we investigated whether PQ could induce EMT in AT2 through transforming growth factor β1(More)
OBJECTIVE To observe the protein expression of c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in normal skin and keloid and to explore their influences on the formation of kloid. METHODS Keloid tissues and normal skin tissues were collected from 16 keloid resection patients (experimental group) and 10 voluntary plastic(More)
Background To identify differentially expressed miRNAs profiles in bronchoalveolar lavage fluid (BALF) from patients with silicosis and consider the potential contribution of miRNAs to silicosis.Methods miRNAs expression profiling were performed in the cell fraction of BALF samples obtained from 9 subjects (3 silicosis observation subjects, 3 stage I and(More)
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