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A Novel Coronavirus from Patients with Pneumonia in China, 2019
TLDR
Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
TLDR
In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit.
Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China
TLDR
The duration of the negative conversion of SARS-CoV-2 RNA and its association with the severity of critically ill patients with COVID-19 should be seriously considered and further studied.
Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients
TLDR
These morphological changes in the testes of COVID-19 patients indicate that SARS-CoV-2 infection may impair male GC development and eventually lead to GC loss, and the presence of apoptosis and inflammatory reactions in thetesticular cells is investigated.
Plasma metabolomic and lipidomic alterations associated with COVID-19
TLDR
Untargeted metabolomic and lipidomic analyses of plasma from a cohort of COVID-19 patients who had experienced different symptoms found the metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected patient metabolism.
DVT incidence and risk factors in critically ill patients with COVID-19
TLDR
High incidence of DVT was identified in patients with critically ill COVID-19, despite the use of guideline-recommended pharmacologic thromboprophylaxis, and the presence of hypoalbuminemia, higher SOFA score, and elevated D-dimer were significant DVT risk factors in multivariable analyses.
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