Dingchuan Xue

Learn More
In Caenorhabditis elegans, apoptosis in germ cells is mediated by the same core apoptotic machinery that controls apoptosis in somatic cells. These include the CED-3 caspase, the CED-3 activator CED-4, and the cell death inhibitor CED-9. However, germline apoptosis also differs from somatic apoptosis in its regulation. We found that CSP-3, a caspase homolog(More)
Recognition of phosphatidylserine (PtdSer) is essential for engulfment of apoptotic cells by mammalian phagocytes. Engagement of a new phosphatidylserine-specific receptor (PtdSerR) appears to be necessary for uptake of apoptotic cells. Many other mammalian receptors have been described to function in the clearance of apoptotic cells. The emerging picture(More)
1 Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA * Corresponding author: B Fadeel, Division of Molecular Toxicology, Institute of Environmental Medicine, Nobels väg 13, Karolinska(More)
The past decade experienced a stunning change in the incidence and fatality rates of pesticide poisonings in China. A study on representative case records of pesticide poisoning in a chinese province is presented here. A three-fold increase in poisoning cases due to a lack of preventive measures was reported at the beginning of the 1980s, under the rural(More)
In C. elegans, apoptosis in germ cells is mediated by the same core apoptotic machinery that controls apoptosis in somatic cells. These include the CED-3 caspase, the CED-3 activator CED-4, and the cell death inhibitor CED-9. However, germline apoptosis also differs from somatic apoptosis in its regulation. We found that CSP-3, a caspase homolog that blocks(More)
  • 1