Dinesh N Gandhi

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Urine samples of workers in a small-scale unit manufacturing Direct Black 38 were analyzed by high-pressure liquid chromatography for the presence of benzidine and mono and diacetyl benzidine. Acetylated metabolites were found in all the urine samples, and benzidine was found in all except two. Two workers excreted very high levels of benzidine and its(More)
Biochemical and histopathological studies were performed on the testes of rats after feeding lead acetate at a concentration of 0.25, 0.50 and 1.0 g/l over a period of 60 days. Testicular atrophy along with cellular degeneration was conspicuous at 1 g/l. Furthermore, high cholesterol concentration and significantly low ascorbic acid concentration were found(More)
Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium. Preparations incubated in excess Ca++ (4.2 mM) or in Ca++-free Krebs solution showed decrease in sensitivity to NE. The inhibitory action of(More)
The effects of varying the concentration of Mg++ in the incubation medium on the contractile responses of rat isolated seminal vesicle to 5-hydroxytryptamine (5-HT) were investigated in the absence and presence of EDTA. Preparations incubated in Mg++-free and Mg++ excess media showed supersensitivity and subsensitivity to 5-HT respectively. In the presence(More)
Effect of lithium on the contractile responses of rat isolated seminal vesicle to 5-hydroxytryptamine (5-HT) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium in the absence and presence of EDTA. Preparations incubated in excess Ca++ (4.2 mM) or in Ca++-free Krebs solution showed decrease in sensitivity to 5-HT, whereas(More)
Fish and other aquatic organisms are important source of dietary proteins for the human population. Fish meat, however, is contaminated with methyl mercury (MeHg), a potent neurotoxin. The well known Minamata and Niigata epidemic outcomes in Japan have raised the awareness of the health risk resulting from consumption of fish (and shellfish) from water(More)
To characterize developmental and behavioral alterations induced by arsenic exposure, Albino rats were exposed to arsenic (0, 1.5, 3.0 and 4.5 mg/kg/day/po) from gestation day 8 to till parturition and the offspring were observed over the first 3 postnatal weeks, until they were weaned on post-natal day (PND) 21. Once the pups were delivered (PND0), the(More)
Devadaru compound was shown to be beneficial in Tamak Swasa (bronchial asthma). Clinical findings revealed higher percentage of relief in cardinal and general symptoms with decrement in the pulse rate and in the respiration rate. A significant linear increase in PEFR value was observed before and after treatment and an increase in FEV1 values measured in(More)
The effect of hexachlorocyclohexane (HCH) treatment in male albino rats at dosages of 3 and 6 mg/kg body weight by force-feeding were studied over a period of 180 days. Histological observations revealed graded degeneration in the muscular layer of vas deferens. Moreover, the accumulation of HCH residue in serum and vas deferens is highly significant in the(More)
BACKGROUND Nicotine and cigarette smoking (CS) are associated with addiction behavior, drug-seeking, and abuse. However, the mechanisms that mediate this association especially, the role of brain-derived neurotrophic factor (BDNF), dopamine (DA), and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in the cerebral cortex, are not fully known.(More)