Dinesh M Tripathi

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UNLABELLED Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2 ), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor. This study investigated whether terutroban, a specific TP(More)
The effects of subtoxic levels of Cr on humoral and cell-mediated immune responses, blood parameters, susceptibility to bacterial (Aeromonas hydrophila) infection, and macrophage activity in the freshwater air-breathing Asian catfish, Saccobranchus fossilis, during a 28-day exposure were examined by a static bioassay test procedure. At 0.1, 1.0, and 3.2 mg(More)
A population based case-control study was designed to explore the genetic risk factors for hepatitis B virus (HBV) related liver disease susceptibility. A total of 424 subjects comprising 210 controls, 50 acute HBV (AVH), 84 chronic HBV (CHBV), 25 HBV related cirrhosis and 55 HBV related hepatocellular carcinoma (HCC) cases were included in the study.(More)
Immunologic responses and stereoscan analysis of the skin and gill surfaces were performed in the air-breathing catfish, Saccobranchus fossilis (Bloch) following sublethal exposure to copper. At 0.056, 0.1, and 0.32 mg/liter of Cu, a dose-dependent decrease in red and white blood cell counts, hemoglobin content, and packed cell volume values were observed(More)
BACKGROUND & AIMS Recent studies have shown a pathological role of angiogenesis in the progression of chronic liver diseases (CLDs). The present study focused on numbers and angiogenic functions of circulating endothelial progenitor cells (EPCs) in patients with cirrhosis. METHODS Circulating EPCs were counted by flow-cytometry, and correlated with(More)
BACKGROUND & AIMS Increased hepatic vascular resistance due to fibrosis and elevated hepatic vascular tone is the primary factor in the development of portal hypertension. Heparin may decrease fibrosis by inhibiting intrahepatic microthrombosis and thrombin-mediated hepatic stellate cell activation. In addition, heparin enhances eNOS activity, which may(More)
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and systemic hemodynamics in cirrhotic rats and its possible interaction with the(More)
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