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OCCURRENCE OF SIDE EFFECTS FROM ANTI-TUBERCULOSIS DRUGS IN URBAN NEPALESE POPULATION UNDER DOTS TREATMENT
TLDR
Tuberculosis is one of the foremost public health problems causing an enormous burden of suffering and deaths and timely detection and temporary withdrawal of the offending agent can completely cure anti-tuberculosis drugsinduced side effects. Expand
Biosynthesis of the nargenicin A1 pyrrole moiety from Nocardia sp. CS682
TLDR
The evidences are presented that the pyrrole moiety of nargenicin A1 was also derived from l-proline by the coordinated action of three proteins, NgnN4 (proline adenyltransferase),NgnN5 (Proline carrier protein), and Ngn ngnN3 (flavine-dependent acyl-coenzyme A dehydrogenases). Expand
Effect of different biosynthetic precursors on the production of nargenicin A1 from metabolically engineered Nocardia sp. CS682.
TLDR
Overall results showed that among the supplements, methyl oleate was the most effective precursor supporting the highest titers of nargenicin A1 in Nocardia sp. Expand
Metabolic Engineering of Nocardia sp. CS682 for Enhanced Production of Nargenicin A1
TLDR
A metabolic engineering approach based on recombinant DNA technology is applied in order to boost the production of nargenicin A1 from Nocardia sp. Expand