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Chaperone-mediated autophagy (CMA) targets soluble proteins for lysosomal degradation. Here we found that CMA was activated in T cells in response to engagement of the T cell antigen receptor (TCR), which induced expression of the CMA-related lysosomal receptor LAMP-2A. In activated T cells, CMA targeted the ubiquitin ligase Itch and the calcineurin(More)
Fasciola gigantica, causative agent of tropical fasciolosis, inflicts substantial economic losses on the livestock industry, affecting severely buffalo productivity in the tropical countries. Very few vaccination trials with different target antigens against F. gigantica infection have been conducted in this host. Present study describes a vaccination trial(More)
BACKGROUND Education of mothers may improve child health. We investigated whether maternal health literacy, a rapidly modifiable factor related to mother's education, was associated with children's receipt of vaccines in two underserved Indian communities. METHODS Cross-sectional surveys in an urban and a rural site. We assessed health literacy using(More)
Success of cancer vaccination is strongly hampered by immune suppression in the tumor microenvironment (TME). Interleukin (IL)-6 is particularly and highly produced by triple-negative breast cancer (TNBC) cells, and has been considered as an important contributor to immune suppression in the TME. Therefore, we hypothesized that IL-6 reduction may improve(More)
— Over the past decade, several adiabatic logic styles have been reported. This paper deals with the design of a 1-bit full adder using several adiabatic logic styles, which are derived from static CMOS logic, without a large change. The full adders are designed using 180nm technology parameters provided by predictive technology and simulated using HSPICE.(More)
There are numerous real time & operation critical systems in which the failure of the system is unacceptable at any stage of processing. The examples of such systems are like ATM machines, satellites, spacecraft etc. In this paper a fault tolerant microprocessor is developed by using checker units with a fault secure ALU and to develop a fault secure ALU(More)
Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor cells, i.e., immature macrophages, granulocytes, and dendritic cells (DCs), that are endowed with a robust immunosuppressive activity. 1 In normal healthy individuals, immature myeloid cells differentiate into mature granulocytes, macrophages, and DCs. Conversely,(More)