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- Monica Kong-Beltran, Somasekar Seshagiri, +13 authors Robert L. Yauch
- Cancer research
- 2006
Activating mutations in receptor tyrosine kinases play a critical role in oncogenesis. Despite evidence that Met kinase is deregulated in human cancer, the role of activating mutations in cancers… (More)
- Mark Peek, Paul James Moran, Nerissa Mendoza, Dineli Wickramasinghe, Daniel Kirchhofer
- The Journal of biological chemistry
- 2002
Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase c-Met, is composed of an alpha-chain containing four Kringle domains (K1-K4) and a serine protease domain-like beta-chain.… (More)
- Brian S Lucas, W Scott Aaron, +20 authors Wendy Zhong
- Bioorganic & medicinal chemistry letters
- 2010
The Hedgehog (Hh) signaling pathway regulates cell proliferation and differentiation in developing tissues, and abnormal activation of the Hh pathway has been linked to several tumor subsets. As a… (More)
- Zhihong Li, Xianghong Wang, +48 authors Julio C. Medina
- Journal of medicinal chemistry
- 2014
We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine derivatives was… (More)
- Cong Li, Lingming Liang, +8 authors Kang Dai
- 2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC
Objectives: Flt3 inhibitors have shown clinical responses in Flt3 mutant acute myeloid leukemia (AML) but resistance… (More)
- Hilary P. Beck, Todd J. Kohn, +14 authors Wang Shen
- Bioorganic & medicinal chemistry letters
- 2008
The LPA(2) protein is overexpressed in many tumor cells. We report the optimization of a series of LPA(2) antagonists using calcium mobilization assay (aequorin assay) that led to the discovery of… (More)
- Matthew Lee Brown, W Scott Aaron, +18 authors Michael Gilbert Johnson
- Bioorganic & medicinal chemistry letters
- 2011
A bis-amide antagonist of Smoothened, a seven-transmembrane receptor in the Hedgehog signaling pathway, was discovered via high throughput screening. In vitro and in vivo experiments demonstrated… (More)