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  • Christina Brock, Eirik Søfteland, Veronica Gunterberg, Jens Brøndum Frøkjær, Dina Lelic, Birgitte Brock +4 others
  • 2013
OBJECTIVE Long-term diabetes leads to severe peripheral, autonomous, and central neuropathy in combination with clinical gastrointestinal symptoms. The brain-gut axis thus expresses a neurophysiological profile, and heart rate variability (HRV) can be correlated with clinical gastrointestinal symptoms. RESEARCH DESIGN AND METHODS Fifteen healthy(More)
Inverse modeling is typically applied to instantaneous electroencephalogram signals. However, this approach has several shortcomings including its instability to model multiple and deep located dipole sources and the interference of background noise may hamper the sensitivity, stability, and precision of the estimated dipoles. This article validates(More)
We present a method for segmenting evoked potentials into functional micro-states. The method is based on measuring the similarity between all the topographic maps in the evoked potential and grouping them into functional micro-states based on minimizing an error function. The similarity is measured as the normalized cross-correlation coefficient. The(More)
INTRODUCTION Several brain structures have been consistently found to be involved in visceral pain processing. However, recent research questions the specificity of these regions and it has been suggested that it is not singular activations of brain areas, but their cross-communication that results in perception of pain. Moreover, frequency at which neurons(More)
INTRODUCTION By using a novel brain source modeling approach, where the evoked potential (EP) signal was decomposed with multichannel matching pursuit (MMP) before source localization, we investigated brain generators of EPs after a pain stimulus in the esophagus before and after administration of placebo/morphine. We showed that this new approach of(More)
Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology.(More)
Objectives. Studies have shown decreases in N30 somatosensory evoked potential (SEP) peak amplitudes following spinal manipulation (SM) of dysfunctional segments in subclinical pain (SCP) populations. This study sought to verify these findings and to investigate underlying brain sources that may be responsible for such changes. Methods. Nineteen SCP(More)
INTRODUCTION Multichannel matching pursuit (MMP) is a relatively new method that can be applied to electroencephalogram (EEG) signals in combination with inverse modelling. However, limitations of MMP have not been adequately tested. The aims of this study were to investigate how the accuracy of MMP algorithm is altered due to increased number of brain(More)
BACKGROUND/AIMS In various chronic pain conditions cortical reorganisation seems to play a role in the symptomatology. The aims of this study were to investigate cortical reorganisation in patients with pain caused by chronic pancreatitis (CP) and to correlate putative cortical reorganisation to clinical pain scores. METHODS 24 patients suffering from CP(More)