Dimitrios P. Sokolis

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OBJECTIVE We sought to examine in age-matched subjects the biomechanical and compositional remodeling associated with ascending thoracic aortic aneurysms according to region and direction. METHODS Whole, fresh, degenerative ascending thoracic aortic aneurysms were taken from 26 patients (age, 69 +/- 2 years; maximum aortic diameter, 5.9 +/- 0.3 cm) during(More)
This study aimed to assess regional and directional differences in the mechanical properties of ascending thoracic aortic aneurysms (ATAA). Whole fresh ATAA were taken from twelve patients, undergoing elective surgical repair, and cut into tissue specimens. These were divided into groups according to direction and region, and subjected to uniaxial testing(More)
AIM This study assessed segmental changes in the mechanical properties of the aorta at low, physiologic and high stresses, in relation with wall composition and morphometry. METHODS The aorta of 10 healthy pigs was divided into six thoracic and three abdominal segments. Aortic specimens were mechanically tested to failure, i.e. rupture, using a uniaxial(More)
The passive elastic characteristics of the abdominal aorta were investigated in two experimental animal models, aiming at assessing the stress-strain relation of the aortic wall. Twenty porcine and 15 rabbit healthy abdominal aortas were subjected to uniaxial stress-strain analysis, performed on a tensile-testing device, while immersed in a physiologic(More)
Ascending thoracic aortic aneurysms (ATAA) were resected from patients during graft replacement and non-aneurysmal vessels during autopsy. Tissues were histomechanically tested according to region and orientation, and the experimental recordings reduced with a Fung-type strain--energy function, affording faithful biomechanical characterisation of the vessel(More)
INTRODUCTION Aortic function is an important determinant of pressure and flow in the entire cardiovascular system. This study aimed at evaluating segmental differences of aortic function and composition, in order to understand their clinical implications. METHODS The thoracic aorta from each of 20 healthy pigs was divided into four and the abdominal into(More)
A constitutive law that includes three analytical expressions was recently proposed to approximate the low, physiologic, and high-stress parts of the aortic stress-strain relation in uniaxial tension, consistent with the biphasic nature of the aortic wall under passive conditions. This consistency, and the fact that previous phenomenological uniaxial laws(More)
This study addressed layer-specific differences in the biomechanical response of ascending aortic aneusysms, obtained from patients during graft replacement. Tensile tests were conducted on pairs of (orthogonally directed) intimal, medial, and adventitial strips from the anterior, posterior, and two lateral quadrants. The experimental data were reduced by(More)
We hypothesized that female gender may have a specific negative impact on the mechanical characteristics, composition, and expression of matrix metalloproteinases/tissue inhibitors (MMPs/TIMPs) in the wall of ascending thoracic aortic aneurysms (ATAAs). Degenerative ATAAs were resected from 35 patients (age: 67±2 years, male: 20, ATAA diameter: 5.5±0.1cm)(More)
BACKGROUND AND AIM The consumption of olive oil has been associated with lower incidence of cardiovascular disease in the Mediterranean countries. This may be due in part to the action of platelet-activating factor (PAF) antagonists which we have previously demonstrated to be present in olive oil. In order to assess the in vivo effects of olive oil lipids(More)