Dimitrios Matamis

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RATIONALE Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear. OBJECTIVES To estimate whether mortality in mechanically ventilated patients has changed over time. METHODS Prospective cohort studies conducted in 1998, 2004, and(More)
A new law or an amendment to existing law has already been incorporated in national statutes or is in the process of approval in The Netherlands, France, Belgium, Italy, Denmark, Germany, Austria, and Spain (Table 1). In other countries discussions and proposals are still not complete. In some countries the proposals are limited to drug research (as was(More)
To investigate the influence of continuous haemofiltration (CHF) on haemodynamics, gas exchange and core temperature in critically ill septic patients with acute renal failure. In 20 patients (17 male, 3 female) ultrafiltration rate, core temperature, gas exchange and haemodynamic variables were measured at regular intervals during the first 48 h of(More)
To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients. International prospective cohort study. Three hundred sixty-one intensive care units from 20 countries. Five thousand one hundred eighty-three patients mechanically ventilated for(More)
The use of ultrasonography has become increasingly popular in the everyday management of critically ill patients. It has been demonstrated to be a safe and handy bedside tool that allows rapid hemodynamic assessment and visualization of the thoracic, abdominal and major vessels structures. More recently, M-mode ultrasonography has been used in the(More)
BACKGROUND Diaphragmatic muscle contractions triggered by ventilator insuffl ations constitute a form of patient-ventilator interaction referred to as “entrainment,” which is usually unrecognized in critically ill patients. Our objective was to review tracings, which also included muscular activity, obtained in sedated patients who were mechanically(More)
To report the importance of hypertrophic obstructive cardiomyopathy as a potential substrate for difficult weaning from mechanical ventilation. Case report in an adult intensive care unit of a tertiary care hospital. Two patients who developed intractable pulmonary edema with subsequent difficult weaning from mechanical ventilation in the early(More)
There are limited data available about the role of sedation and analgesia during noninvasive positive pressure ventilation (NPPV). The objective of study was to estimate the effect of analgesic or sedative drugs on the failure of NPPV. We studied patients who received at least 2 h of NPPV as first-line therapy in a prospective observational study carried(More)
To investigate the respiratory, metabolic and hemodynamic effects of clonidine in ventilated patients presenting with withdrawal syndrome after sedation interruption. Prospective, interventional, single-center study in 30 ventilated ICU patients. Metabolic [oxygen consumption (VO2), CO2 production (VCO2), resting energy expenditure (REE)], respiratory(More)
Objective: To evaluate resting energy expenditure (REE) in brain dead patients and to investigate the hypothesis that the reduction in REE results from a decrease in cerebral blood flow. Design: Prospective, open labeled, control study. Setting: General intensive care unit of a tertiary referral teaching hospital. Patients: 30 critically ill patients with(More)