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Neural responses are modulated by brain state, which varies with arousal, attention, and behavior. In mice, running and whisking desynchronize the cortex and enhance sensory responses, but the quiescent periods between bouts of exploratory behaviors have not been well studied. We found that these periods of "quiet wakefulness" were characterized by state(More)
Neural codes are believed to have adapted to the statistical properties of the natural environment. However, the principles that govern the organization of ensemble activity in the visual cortex during natural visual input are unknown. We recorded populations of up to 500 neurons in the mouse primary visual cortex and characterized the structure of their(More)
Most upper limb prosthesis controllers only allow the individual selection and control of single joints of the limb. The main limiting factor for simultaneous multi-joint control is usually the availability of reliable independent control signals that can intuitively be used. In this paper, a novel method is presented for extraction of individual muscle(More)
Ambitious projects aim to record the activity of ever larger and denser neuronal populations in vivo. Correlations in neural activity measured in such recordings can reveal important aspects of neural circuit organization. However, estimating and interpreting large correlation matrices is statistically challenging. Estimation can be improved by(More)
We trained a rhesus monkey to perform randomly cued, individuated finger flexions of the thumb, index, and middle finger. Nine Implantable MyoElectric Sensors (IMES) were then surgically implanted into the finger muscles of the monkey's forearm, without any observable adverse chronic effects. Using an inductive link, we wirelessly recorded EMG from the IMES(More)
The rise of big data in modern research poses serious challenges for data management: Large and intricate datasets from diverse instrumentation must be precisely aligned, annotated , and processed in a variety of ways to extract new insights. While high levels of data integrity are expected, research teams have diverse backgrounds, are geographically(More)
The neural code is believed to have adapted to the statistical properties of the natural environment. However, the principles that govern the organization of ensemble activity in the visual cortex during natural visual input are unknown. We recorded populations of up to 500 neurons in the mouse primary visual cortex and characterized the structure of their(More)
Cell Matrix is a parallel self-configurable architecture. It is similar to field programmable gate arrays (FPGAs) in that Cell Matrix elements can be programmed. Cell Matrix circuits differ from FPGAs because groups of their elements can dynamically reprogram adjacent elements. Advanced behaviors arise from this ability, setting Cell Matrix apart from(More)
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