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Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines.

• Dimitri Moreau, Christophe Tomasoni, +8 authors Christos Roussakis
• Environmental toxicology and pharmacology
• 2006

The antiproliferative activities of several extracts from cultivated microalgae in France have been studied against bronchopulmonary and epithelial cell lines, respectively (A549, NSCLC-N6 and SRA… (More)

Cytotoxic lupane-type triterpenoids from Acacia mellifera.

• Charles Mutai, Dennis Abatis, Constantinos Vagias, Dimitri Moreau, Christos Roussakis, Vassilios Roussis
• Phytochemistry
• 2004

One new and eight previously described lupane-type metabolites were isolated for the first time from Acacia mellifera (Leguminosae). Based on spectral analyses, the structure of the new compound was… (More)

An extract from the brown alga Bifurcaria bifurcata induces irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma line

• Dimitri Moreau, Hélène Thomas-Guyon, +5 authors Christos Roussakis
• Journal of Applied Phycology
• 2005

In this study, the antiproliferative activity of a crude extract isolated from Bifurcaria bifurcata (Velley) Ross, a common marine brown alga of the Atlantic shores of Europe, was investigated. Its… (More)

Lupane triterpenoids from Acacia mellifera with cytotoxic activity.

• Charles Mutai, Dennis Abatis, Constantinos Vagias, Dimitri Moreau, Christos Roussakis, Vassilios Roussis
• Molecules
• 2007

Three new pentacyclic triterpenoids: (20R)-3-oxolupan-30-al (1), (20S)-3-oxolupan-30-al (2) and (20R)-28-hydroxylupen-30-al-3-one (3), along with (20S)-3beta-hydroxylupan-30-al (4), the latter… (More)

Cytotoxic activity of Origanum dictamnus.

• Ioanna Chinou, Christos Liolios, Dimitri Moreau, Christos Roussakis
• Fitoterapia
• 2007

Several extracts of Origanum dictamnus, an endemic plant of Greece growing only in the island of Crete and the bioassay-directed isolated ursolic acid, were tested in vitro against the P388 (murine… (More)

Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer.

• Dimitri Moreau, Catherine Jacquot, +7 authors Christos Roussakis
• International journal of cancer
• 2008

Despite our growing insight into carcinogenesis, treatment of tumors, especially nonsmall cell lung cancer (NSCLC), remains limited and it is urgent to develop strategies that target tumor cells and… (More)

Selective Imaging of Late Endosomes with a pH-Sensitive Diazaoxatriangulene Fluorescent Probe.

• Antoine Wallabregue, Dimitri Moreau, +6 authors Jérôme Lacour
• Journal of the American Chemical Society
• 2016

Late endosomes are a major trafficking hub in the cell at the crossroads between endocytosis, autophagy, and degradation in lysosomes. Herein is disclosed the first small molecule allowing their… (More)

Two New Triterpenoids from Acacia mellifera ( Vahl ) Benth

• Charles Mutai, Dennis Abatis, Constantinos Vagias, Dimitri Moreau, Christos Roussakis, Vassilios Roussis
• 2006

Two new pentacyclic triterpenoids, (20R) 3-oxolupane-30al (1), and (20S) 3-oxolupane-30al (2), along with six known metabolites; 30-hydroxylup-20 (29)-en-3-one (3), 30-hydroxylup20 (29)-en-3ß-ol (4),… (More)

C4-Substituted Isoquinolines: Synthesis and Cytotoxic Action

• Andrew Tsotinis, S Zouroudis, Dimitri Moreau, Christos Roussakis
• The open medicinal chemistry journal
• 2007

A facile synthesis of the C4-substituted isoquinolines 5a-c and 6a-c is described. Commercially available 4-bromoisoquinoline is converted to the alpha,beta-unsaturated esters 8 and 10 on treatment… (More)

Proliferation arrest in G1 phase of a non-small cell lung cancer cell line (NSCLC-N6) treated by an original compound methyl-4-methoxy-3-(3-methyl-2-butanoyl) benzoate (VT1) independently of the…

• Catherine Jacquot, Dimitri Moreau, +4 authors Christos Roussakis
• International journal of oncology
• 2003

Non-small cell lung cancers remain difficult to treat and have a high death rate and poor 5-year survival. New therapeutic strategies are urgently needed, which should be more specific for the cancer… (More)

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