Dimitri Abrams

Learn More
Measurement of transendothelial or transepithelial electrical resistances (TERs) is a straightforward in situ experimental approach to monitor the expression or modulation of barrier-forming cell-to-cell contacts (tight junctions) in cultured cells grown on porous filters. Although widely accepted, there is currently no device available to automatically(More)
The motoric effects of the D1-like agonist SKF 38393 (5.0 or 20.0 mg/kg) and the D2-like agonist quinpirole (0.2, 1.0, or 3.0 mg/kg) were determined in adult rats treated with 6-OHDA (100 micrograms) or its vehicle on postnatal Day 3. Quinpirole, but not SKF 38393, produced stereotypy and modest motor activity in vehicle-treated rats. These effects of(More)
The ontogeny of apomorphine-induced stereotypy in rats treated with 6-OHDA (100 micrograms) or its vehicle on postnatal Day 3 was determined on Days 6, 21, or 60-90. Stereotypic sniffing and mouthing behavior were produced by apomorphine in control and DA-depleted animals as early as Day 6. Animals depleted of DA as neonates exhibited supersensitivity to(More)
  • 1