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Gram-positive pathogens mainly, Staphylococcus aureus, Enterococcus and coagulase-negative Staphylococcus, are developing increasing resistance to glycopeptides that pose a problem in treating infections caused by these pathogens. Vancomycin is the treatment of choice in treating methicillin-resistant S. aureus (MRSA). Community-acquired MRSA is associated(More)
The Future Combat Systems (FCS) program is developing the FCS System of Systems Simulation Environment (FSE) to provide the "real world wraparound" to the FCS System of Systems Simulation Framework (S2F). A primary component of the FCS is the Communication Effects Server (CES) whose objective is to develop a flexible, scalable, and high-performance,(More)
DHH superfamily includes RecJ, nanoRNases (NrnA), cyclic nucleotide phosphodiesterases and pyrophosphatases. In this study, we have carried out in vitro and in vivo investigations on the bifunctional NrnA-homolog from Mycobacterium smegmatis, MSMEG_2630. The crystal structure of MSMEG_2630 was determined to 2.2-Å resolution and reveals a dimer consisting of(More)
In cloud, processing loads arrive from many users at random time instants in the form of task. A proper resource allocation policy attempts to assign this task to available VMs on different host so to complete the execution of the tasks in the shortest possible time with minimum power consumption. The complexity of the resource allocation problem with cloud(More)
  • Anand Kumar Andiappan, Rossella Melchiotti, Tuang Yeow Poh, Michelle Nah, Kia Joo Puan, Elena Vigano +21 others
  • 2015
Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering(More)