Dietrich W. Lübbers

Learn More
It has been known since 1851 that atmospheric oxygen is taken up by the human epidermis. The contribution to total respiration is negligible. Until now the significance for the local oxygen supply of the skin has remained unknown. With a newly developed sensor, the oxygen fluxoptode, it has become possible to make local measurements of the transcutaneous(More)
BACKGROUND The spontaneously hypertensive rat (SHR) has oxidative stress and enhanced O2 usage (Q(O2)) relative to tubular sodium transport (TNa). Angiotensin II (Ang II) acting on Type I receptors (AT1-R) causes renal oxidative stress and functional nitric oxide (NO) deficiency that could enhance O2 usage. Therefore, we investigated the hypothesis that(More)
BACKGROUND The kidney has a high rate of oxygen usage (QO2) that is closely dependent on tubular Na+ transport (TNa). However, little is known concerning the regulation of the cortical partial pressure of oxygen (pO2). METHODS First, the pO2 was measured in the outer cortical proximal (PT) and distal tubules (DT), efferent arterioles (EA), and superficial(More)
A microcoaxial needle sensor with a tip diameter of ca. 0.7 microm was used as a microprobe to measure profiles of dissolved oxygen tension (DOT) within fixed pellets of Penicillium chrysogenum as a function of the DOT level around the pellet, in the presence and absence of bulk convective flow and turbulence. The investigations indicate that the oxygen(More)
1. The distribution of oxygen tension has been measured in the carotid body of 97 cats using platinum microelectrodes. In only seven cats was there evidence from measurement of chemoreceptor afferent discharge in the sinus nerve of damage to carotid body tissue or blood vessel. 11 carotid bodies were histologically controlled, 2 showed obvious damages of(More)
Using a newly developed platinum-O2-microeletrode [30] based on the design ofSilver [37] the construction and properties of which are described,pO2-measurements in the parenchyma of the blood-perfused and the cell-free perfused rat kidney were carried out. By continuous recording of thepO2 during slow (150 μ×min−1) insertion of the O2-electrode into the(More)
Microflow was continuously recorded at four sites of the brain cortex (cat) during and after direct electrical stimulation of the brain. In some experiments local oxygen partial pressure (PO2) was additionally measured with a new combined element in the same capillary area where microflow was determined. This simultaneous measurement of both microflow and(More)