Dietrich Schneider-Helmert

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Sleep laboratory and outpatient studies of the hypnotic efficacy of the amino acid L-tryptophan are reviewed, with particular emphasis on evaluation of therapeutic effectiveness in the treatment of insomnia. In younger situational insomniacs, whose sleep problem consists solely of longer than usual sleep latencies, L-tryptophan is effective in reducing(More)
A comparison was made between 16 middle-aged chronic insomniacs and 16 normal sleepers, matched by age and sex, in a psychophysiological study, including polysomnographic night sleep recordings, MMPI personality profiles, testing of cognitive performance, and relaxation capability during daytime. Both objective and subjective criteria of night sleep(More)
Psychobiological aspects of low-dose benzodiazepine dependence (LBD) and drug withdrawal were investigated in 76 middle-aged and elderly chronic insomniacs in a sleep laboratory. Comparison with drug-free insomniacs showed that LBD leads to a complete loss of hypnotic activity and substantial suppression of delta and REM sleep. Only small differences were(More)
Intrusion of alpha activity, an electroencephalographic (EEG) pattern typical for wakefulness, into sleep stages has repeatedly been described and investigated in various populations. Some studies suggested that it is a less deep and restorative sleep, but others did not support this interpretation. The present study was carried out to collect ample data on(More)
A considerable proportion of chronic non-organic pain patients suffer from insomnia, and alpha sleep has been suggested to be specifically associated with fibromyalgia. However, the clinical significance of those symptoms is not clear. This study was carried out to investigate this question. Twenty-six middle-aged, non-organic pain patients complaining of(More)
The hypothesis that raising blood pressure (BP) during human sleep, by intravenous administration of angiotensin II, causes arousals was tested. BP was measured intraarterially during polygraphic sleep recordings. Twenty-seven intrasleep elevations of BP in two young adults over 2 nights were evaluated. The BP increases ranged from 16% to 74% of the(More)
Interval therapy is the concept of intermittent applications with drug-free intervals, based on the observation that in many cases L-tryptophan has the best effects on disturbed sleep during the drug-free interval after-short-term application. This concept was formulated as an experimental hypothesis to be tested in the sleep laboratory in a predictive,(More)
Data on subjective estimates and polygraphic measures of total sleep time and sleep latency were collected from the literature and analyzed for accordance or discrepancy between subjective and objective (EEG-based) mean values in experiments on acute treatment of insomnia by benzodiazepine hypnotics. In baseline placebo conditions there was a tendency to(More)
This paper summarizes different investigations into effects of delta sleep-inducing peptide (DSIP) injections on insomnia. Two different studies showed improvement of sleep following single injections of 25 nmol/kg b.w. before sleep. Repeated administrations indicated a buildup with normalization of sleep structure after four administrations. Repeated(More)