Dietrich Lehner

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Nitric oxide synthases (NOSs), which catalyze the formation of the ubiquitous biological messenger molecule nitric oxide, represent unique cytochrome P-450s, containing reductase and mono-oxygenase domains within one polypeptide and requiring tetrahydrobiopterin as cofactor. To investigate whether tetrahydrobiopterin functions as an allosteric effector of(More)
Neuronal nitric-oxide (NO) synthase contains FAD, FMN, heme, and tetrahydrobiopterin as prosthetic groups and represents a multifunctional oxidoreductase catalyzing oxidation of L-arginine to L-citrulline and NO, reduction of molecular oxygen to superoxide, and electron transfer to cytochromes. To investigate how binding of the prosthetic heme moiety is(More)
Knowledge is an important matter for consulting firms − as a resource, as a product or service, and as a trigger for internal value creation processes. Therefore, a strategy for management and utilisation of knowledge in its different state is needed. It is sensible to assume, that this strategy is strongly influenced by a respective consulting firm's(More)
Limited proteolysis of cellobiose dehydrogenase (CDH) from the white rot fungus Phanerochaete chrysosporium by papain cleaves the enzyme into two fragments containing flavin (FAD) and heme, respectively. Small-angle X-ray scattering (SAXS) was employed to investigate size and shape of intact CDH and of its fragments in solution. The largest dimension of CDH(More)