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The murine homologue of the human motility-stimulating protein autotaxin (ATX) was identified as a BMP2 upregulated gene by subtractive cloning from mesenchymal progenitors C3H10T1/2 (Bächner, D., Ahrens, M., Betat, N., Schröder, D., Hoffmann. A., Lauber, J., Steinert, P., Flohe, L., Gross, G., 1998. Bmp-2 downstream targets in mesenchymal development(More)
The murine homologue of the human glycoprotein (transmembrane) NMB (GPNMB) gene was identified by subtractive cloning from in vitro cultured murine primary osteoblast cells and subsequent RACE-PCR. GPNMB is a highly glycosylated type I transmembrane protein that shares significant sequence homology to several melanosomal proteins. Increasing expression of(More)
Use of highly integrated application specific circuits (ASICs) in bioelectric data acquisition systems promise important new insights into the origin of a large variety of health problems by providing light-weight, low-power, low-cost medical measurement devices that allow long-term studies. They also promise significant cost reduction in medical care, as(More)
Impact-ionization at low and high electric field as well as the temperature dependence has to be modeled well in order to improve the predictive capability of TCAD tools. The high field behavior is of particular interest for ESD protection devices with low breakdown voltages which are used to protect ICs made with modern technologies. In this paper, the(More)
Cortical attention and habituation parameters are altered in patients suffering from tinnitus. The aim of the study was to quantify cortical attention and habituation parameters in tinnitus patients by recording the contingent negative variation (CNV) response and to correlate amplitudes of different CNV parameters with duration of disease. Twenty patients(More)
Electrical Neurostimulation is useful in several medical therapies, for the treatment of neuromuscular deficits and for restoring physiological and sensory functions. Fully implantable devices are preferable in order to reach high selectivity and to give comfort to the patient. However, smaller devices bring more challenges regarding fabrication techniques(More)
Electrical Neurostimulation has been effective in several medical therapies and also for restoring physiological, sensory and neuromuscular deficits. The rectangular pulse waveform has been used as a standard shape for neural stimulation. However, it has been shown that non-rectangular waveforms provide a more energy-efficient neural stimulation. An ASIC(More)
This paper details an array of switch resistor based memristor emulators with integrate & fire based neuron ASIC for the development of memristor based pattern recognition. The designed ASIC has 4 memristor emulators with a conductance range from 195 nS to 190 uS; processing has been planned to be off-chip to get the freedom of programmability of any(More)
This paper details a fully programmable floating memristor (resistor with memory) emulator ASIC designed for biologically inspired memristive learning. Since real memristor is not commercially available, a compact memristor emulator is needed for device study. The designed ASIC has a memristor emulator with conductance range from 4.88nS to 4.99μS(More)