Dietmar Neubacher

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BACKGROUND This study investigated the cardiovascular (CV) safety profile of the dipeptidyl peptidase (DPP)-4 inhibitor linagliptin versus comparator treatments. METHODS This was a pre-specified meta-analysis of CV events in linagliptin or comparator-treated patients with type 2 diabetes mellitus (T2DM) from eight Phase 3 studies. All suspected CV events(More)
BACKGROUND Tipranavir, a novel protease inhibitor, has demonstrated antiviral activity against protease inhibitor-resistant human immunodeficiency virus type 1 (HIV-1) isolates. The Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST-2) trial is an ongoing, open-label, phase III trial comparing(More)
BACKGROUND The cardiovascular (CV) safety of linagliptin was evaluated in subjects with type 2 diabetes (T2DM). METHODS Pre-specified patient-level pooled analysis of all available double-blind, randomized, controlled trials, ≥ 12 weeks' duration (19 trials, 9459 subjects) of linagliptin versus placebo/active treatment. Primary end point: composite of(More)
In the following a summary of the complete conceptual model for the port problem is given. The problem consists of two ports, one for tankers and one for container ships. In both ports tugboats operate to berth and de-berth ships. The main sequence of activities can be described as follows. Tankers and container ships arrive at a corresponding harbor site(More)
The availability of adequate and sustainable information systems has become one of the most important success factors for operations in safety critical environments, where life and safety of people is at stake. In this paper the development and the implementation of an information system for public safety is presented. In a more than two-year project(More)
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