Dietmar J. Hecker

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The precision of sound information transmitted to the brain depends on the transfer characteristics of the inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. We found that brain derived neurotrophic factor (BDNF) differentially influences IHC characteristics in the intact and injured cochlea. Using conditional knock-out mice(More)
Cav1.3 L-type Ca(2+)-channel function is regulated by a C-terminal automodulatory domain (CTM). It affects channel binding of calmodulin and thereby tunes channel activity by interfering with Ca(2+)- and voltage-dependent gating. Alternative splicing generates short C-terminal channel variants lacking the CTM resulting in enhanced Ca(2+)-dependent(More)
Cervical (c) and ocular (o) vestibular evoked myogenic potentials (VEMPs) provide important tools for measuring otolith function. However, two major drawbacks of this method are encountered in clinical practice. First, recording of oVEMPs is compromised by small n10 amplitudes. Second, VEMP analysis is currently based on the averaging technique, resulting(More)
OBJECTIVE To study the involvement of the different semicircular canals in posttraumatic benign paroxysmal positioning vertigo (BPPV) with special reference to the anterior canal (AC). STUDY DESIGN Retrospective review. SETTING Tertiary referral center. PATIENTS Seventy-four BPPV patients. INTERVENTIONS Neurotologic assessment with(More)
Distortion product otoacoustic emissions (DPOAEs) are widely used as an objective examination procedure to determine cochlear function. In a clinical routine setting, the amplitude of the DPOAE signal at 2f1 .. f2 is applied as an indicator for a potential hearing loss up to 8 kHz. Due to their poor signal to noise ratio, meatal nodes from standing waves(More)
The examination of subcortical auditory processing by macroscopic electrophysiological measurements gains more and more interest in the group of school-age children, especially, in the objective diagnosis of the central auditory processing disorder. At the same time, recent behavioural and animal studies provided indicators for subcortical plasticity and(More)
Inhibitory glycine receptors containing the α3 subunit (GlyRα3) regulate sensory information processing in the CNS and retina. In previous work, we demonstrated the presence of postsynaptic GlyRα3 immunoreactivity at efferent synapses of the medial and lateral olivocochlear bundle in the organ of Corti; however, the role of these α3-GlyRs in auditory(More)
The auxiliary subunit α2δ2 modulates the abundance and function of voltage-gated calcium channels. Here we show that α2δ2 mRNA is expressed in neonatal and mature hair cells. A functional α2δ2-null mouse, the ducky mouse (du), showed elevated auditory brainstem response click and frequency-dependent hearing thresholds. Otoacoustic emissions were not(More)
OBJECTIVE This work presents a computer-based approach to analyze the two-dimensional vocal fold dynamics of endoscopic high-speed videos, and constitutes an extension and generalization of a previously proposed wavelet-based procedure. While most approaches aim for analyzing sustained phonation conditions, the proposed method allows for a clinically(More)
In order to objectively assess the laryngeal vibratory behavior, endoscopic high-speed cameras capture several thousand frames per second of the vocal folds during phonation. However, judging all inherent clinically relevant features is a challenging task and requires well-founded expert knowledge. In this study, an automated wavelet-based analysis of(More)