Dietmar Ferger

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The potential of protease inhibitors E-64, calpain inhibitor I (CPI-I) and MDL28170 to protect hippocampal neurons in an in vitro model of neurotoxicity was investigated. Hippocampal cultures were treated with glutamate, and neurotoxicity was quantified. Glutamate treated cultures exhibited damage to approximately 50% of neurons. In contrast only 20-30% of(More)
BACKGROUND Epidemiological and clinical studies, often including anthropometric measures, have established obesity as a major risk factor for the development of type 2 diabetes. Appropriate cut-off values for anthropometric parameters are necessary for prediction or decision purposes. The cut-off corresponding to the Youden-Index is often applied in(More)
The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil(More)
The purpose of the present study was to examine the relationship between elevation in intracellular Ca2+ concentration ([Ca2+]i) and development of neuronal damage after cytotoxic hypoxia in vitro. Chick telencephalic neurons were exposed to NaCN 1 mM for up to 2 h. [Ca2+]i was assessed by means of fura-2 based microfluorometry and viability was measured by(More)
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