Dieter Scholz

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We describe the identification and in vitro characterization of a series of 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the 20S proteasome. Our initial SAR data demonstrate that the 2-aminobenzylstatine core structure can effectively serve as the basis for designing potent, selective and non-covalent(More)
The capacity of isotype variants of BR55-2, an anti-tumor monoclonal antibody directed against Y oligosaccharide, to mediate antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in the human system was evaluated using freshly isolated peripheral blood mononuclear cells, lymphocytes, monocytes and complement. The ADCC(More)
This paper conducts an investigation towards main aircraft cabin parameters. The aim is two-fold: First, a handbook method is used to preliminary design the aircraft cabin. Second, an objective function representing the “drag in the responsibility of the cabin” is created and optimized using both an analytical approach and a stochastic approach. Several(More)
The 17-alpha-substituted triterpene 1 [(17alpha)-23-(E)-dammara-20,23-diene-3beta,25-diol] showed promising activity in animal models of immunosuppression and inflammation. Using a mouse model for inflammatory skin diseases (oxazolone-induced allergic contact dermatitis, ACD) as the directing in vivo test system, Structure-activity-relationship studies with(More)
This paper looks at fuel consumption due to shaft power off-takes from the engine and the related increase in the aircraft’s fuel consumption. It presents a review and comparison of published and unpublished data on this kind of consumption. The paper presents results from the TURBOMATCH engine simulation model, calibrated to real world engine data. A(More)
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