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OBJECTIVE External validation of three prognostic models in adult intensive care patients in South England. DESIGN. Prospective cohort study. SETTING Seventeen intensive care units (ICU) in the South West Thames Region in South England. PATIENTS AND PARTICIPANTS Data of 16646 patients were analysed. INTERVENTIONS None. MEASUREMENTS AND RESULTS We(More)
OBJECTIVE To assess the effects of discharge Therapeutic Intervention Scoring System (TISS) scores, discharge time and type of discharge facility on ultimate hospital mortality after intensive care. DESIGN Retrospective cohort study. SETTING General intensive care unit (ICU) in a district general hospital. PATIENTS AND PARTICIPANTS One thousand six(More)
We report a case of fatal carbon dioxide embolism and severe haemorrhage during laparoscopic salpingectomy. A sudden decrease in end-tidal carbon dioxide concentration occurred after 1 h of operating time which, together with the clinical signs, suggested carbon dioxide embolism. Haemorrhage after pelvic venous injury was first noted after deflation of the(More)
Forty patients requiring one-lung ventilation (OLV) for thoracic surgery were randomly assigned to receive propofol (4-6 mg kg(-1) h(-1)) or sevoflurane (1 MAC) for maintenance of anaesthesia. Three sets of measurements were taken: (i) after 30 min of two-lung ventilation (TLV), (ii) after 30 min of one-lung ventilation (OLV-1) in the supine position and(More)
Heterotic groups and patterns are of fundamental importance in hybrid breeding. The objectives of our research were to: (1) investigate the relationship of simple sequence repeats (SSR) based genetic distances between populations and panmictic midparent heterosis (PMPH) in a broad range of CIMMYT maize germplasm, (2) evaluate the usefulness of SSR markers(More)
Model customisation is used to adjust prognostic models by re-calibrating them to obtain more reliable mortality estimates. We used two methods for customising the Simplified Acute Physiology Score II model for 15,511 intensive care patients by altering the logit and the coefficients of the original equation. Both methods significantly improved model(More)
BACKGROUND AND OBJECTIVE Efficacy and side-effects of piritramide (pirinitramide) and morphine, given intravenously for postoperative analgesia after hysterectomy, were compared in a randomized controlled double-blind trial in 92 ASA class I-III patients. METHODS Administration was investigator-controlled during the first 90 min and subsequently via a(More)