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Folate fortification of rice by metabolic engineering
Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing twoExpand
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Folates and Folic Acid: From Fundamental Research Toward Sustainable Health
Folates are of paramount importance in one-carbon metabolism of most organisms. Plants and microorganisms are able to synthesize folates de novo, making them the main dietary source for humans andExpand
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Potential impact and cost-effectiveness of multi-biofortified rice in China.
Biofortification, that is, improving the micronutrient content of staple foods through crop breeding, could be a pro-poor, pro-rural, agriculture-based intervention to reduce the health burden ofExpand
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Enhancing pterin and para-aminobenzoate content is not sufficient to successfully biofortify potato tubers and Arabidopsis thaliana plants with folate.
Folates are important cofactors in one-carbon metabolism in all living organisms. Since only plants and micro- organisms are capable of biosynthesizing folates, humans depend entirely on their dietExpand
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Present and future of folate biofortification of crop plants.
Improving nutritional health is one of the major socio-economic challenges of the 21st century, especially with the continuously growing and ageing world population. Folate deficiency is an importantExpand
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Engineering complex metabolic pathways in plants.
Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce theExpand
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Status and market potential of transgenic biofortified crops
25 property rights covering technical standards. Inevitably, there will be trade-offs in the time and resources needed for developing technical standards versus the time and resources needed toExpand
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Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering
Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folateExpand
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Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants
The Arabidopsis DHFR-TS (dihydrofolate reductase-thymidylate synthase) isoform THY3 operates as an inhibitor of its family members, thereby regulating folate and NADPH availability in cells. FolatesExpand
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Genetically Modified Rice with Health Benefits as a Means to Reduce Micronutrient Malnutrition: Global Status, Consumer Preferences, and Potential Health Impacts of Rice Biofortification
Micronutrient malnutrition, characterized by insufficient intake levels of vitamins and minerals, is a major public health problem that affects about 2 billion people worldwide. In order to reduceExpand
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