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BACKGROUND The diagnostic potential of breath analysis has been limited by a lack of knowledge on origin, distribution, and metabolism of the exhaled substances. To overcome this problem, we developed a method to assess trace amounts of hydrocarbons (pentane and isoprene), ketones (acetone), halogenated compounds (isoflurane), and thioethers (dimethyl(More)
Perioperative liver injury due to decreased perfusion may be an underlying mechanism behind the development of systemic inflammatory response syndrome. We designed this animal study to assess whether thoracic epidural anesthesia (TEA) impairs liver oxygenation due to induced hypotension. After ethical approval, 19 anesthetized and acutely instrumented pigs(More)
Akute Symptomexazerbationen bei Palliativpatienten und Patienten am Lebensende haben oftmals eine Alarmierung notfallmedizinischer Strukturen zur Folge und können zu Maßnahmen führen, die vom Patienten nicht gewünscht sind. Im vorliegenden Beitrag sollen Möglichkeiten dargestellt werden, die zu einer Optimierung der notfall- und palliativmedizinischen(More)
The aim of this study was to investigate the impact of the water-soluble poly-(ADP)-ribose-polymerase (PARP) inhibitor 5-aminoisoquinolinone (5-AIQ) on liver microcirculation and function after haemorrhagic shock and resuscitation. Controlled, randomized animal study. University animal care facility and research laboratory. Male Sprague–Dawley rats were(More)
OBJECTIVE The aim of this study was to evaluate the impact of intra-aortic balloon pumping (IABP) on the comparison of simultaneous measurements of cardiac output via pulmonary arterial and transpulmonary thermodilution (PiCCO; Pulsion Medical Systems, Munich, Germany). DESIGN Prospective. SETTINGS University research laboratory. PARTICIPANTS The data(More)
Recent evidence suggests that the hepatic expression of heme oxygenase-1 (HO-1) may preserve hepatocellular integrity after hemorrhagic shock and resuscitation (HR). Because nitric oxide (NO) has been shown to modulate HO-1 expression in cultured cells in vitro, we determined its potential role in the regulation of HO-1 expression after HR in the rat liver(More)
Over the last years several clinical studies have modified the guidelines for preoperative fasting to reduce the risk of pulmonary aspiration. In most western countries the following guidelines are accepted: for clear liquids 2 hours, breast feeding 4 hours, small meals and breast milk substitutes 6 hours, heavy meals 8 hours. Since preoperative smoking is(More)
Palliativmedizin ist seit 2011/2012 verpflichtender Bestandteil des Medizinstudiums (Querschnittfach 13 Palliativ- und Schmerzmedizin). Palliativmedizinische Inhalte sind im Grunde Ausdruck ureigener ärztlicher Aufgaben und sollten entsprechend integraler Bestandteil jeglicher medizinischen/pflegerischen Therapie sein. Palliativmedizinische Angebote in der(More)
INTRODUCTION Acute lung injury (ALI) is an inflammatory disorder of pulmonary or extrapulmonary origin. We have previously demonstrated that netrin-1 dampens murine ALI, and in an attempt to advance this finding into future clinical practice we evaluated whether netrin-1 would reduce alveolar inflammation during porcine ALI. METHODS This was a controlled(More)
BACKGROUND AND OBJECTIVE Despite the introduction of various less-invasive concepts of cardiac output measurement, pulmonary arterial thermodilution is still the most common measurement technique. METHODS This prospective controlled study was designed to compare different methods of cardiac output measurement simultaneously. Pulmonary arterial(More)