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We present results of dynamical simulations of N f = 2 degenerate Wilson twisted mass quarks at maximal twist in the range of pseudo scalar masses 300 MeV m PS 550 MeV. Reaching such small masses was made possible owing to a recently developed variant of the HMC algorithm. The simulations are performed at one value of the lattice spacing a 0.1 fm. In order(More)
OBJECTIVES The aim of this study was to (1) to explore the validity of the depression diagnosis made by the general practitioner (GP) and factors associated with it, (2) to estimate rates of treatment adequacy for depression and factors associated with it and (3) to study how rates of treatment adequacy vary when using different assessment methods and(More)
BACKGROUND The World Health Organization (WHO) has stated that the three leading causes of burden of disease in 2030 are projected to include HIV/AIDS, unipolar depression and ischaemic heart disease. AIMS To estimate health-related quality of life (HRQoL) and quality-adjusted life-year (QALY) losses associated with mental disorders and chronic physical(More)
OBJECTIVE Previous epidemiological studies have revealed a high prevalence of mental disorders among primary care (PC) patients. However, most studies have methodological limitations (e.g. absence of structured clinical interviews, two-phase designs) that affect the generalizability of their results. The main objective of the present study was to estimate(More)
In a recent paper [1] we presented precise lattice QCD results of our Eu-ropean Twisted Mass Collaboration (ETMC). They were obtained by employing two mass-degenerate flavours of twisted mass fermions at maximal twist. In the present paper we give details on our simulations and the computation of physical observables. In particular, we discuss the problem(More)
We present the results of a lattice QCD calculation of the average up-down and strange quark masses and of the light meson pseudoscalar decay constants with N f = 2 dynamical fermions. The simulation is carried out at a single value of the lattice spacing with the twisted mass fermionic action at maximal twist, which guarantees automatic O(a)-improvement of(More)
Twenty-two schizophrenic inpatients were treated for 3 weeks with three randomly fixed oral doses of haloperidol (10, 20, or 30 mg). Analysis of the results by a nonlinear regression model revealed a curvilinear relationship between haloperidol levels in plasma and clinical response, as assessed on the Brief Psychiatric Rating Scale (pseudo-R2 = 0.85, F =(More)
A 24-week, double-blind, randomized trial was performed to compare the efficacy and tolerability of venlafaxine and paroxetine in patients with major depression or dysthymia. Outpatients aged 18-70 years with a baseline score of 17 on the 21-item Hamilton Depression Rating Scale (HAM-D) were eligible. Patients were randomly assigned to venlafaxine, 37.5 mg,(More)
BACKGROUND The 'predictD algorithm' provides an estimate of the level and profile of risk of the onset of major depression in primary care attendees. This gives us the opportunity to develop interventions to prevent depression in a personalized way. We aim to evaluate the effectiveness, cost-effectiveness and cost-utility of a new intervention, personalized(More)
BACKGROUND Within the ICD and DSM review processes there is growing debate on the future classification and status of adjustment disorders, even though evidence on this clinical entity is scant, particularly outside specialised care. AIMS To estimate the prevalence of adjustment disorders in primary care; to explore whether there are differences between(More)