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1. The electrophysiological effects of a series of drugs with Class I antiarrhythmic activity were examined in sheep Purkinje fibres, superfused in vitro with either a normal or hypoxic, hyperkalaemic and acidotic physiological salt solution (PSS). 2. In normal sheep Purkinje fibres, lignocaine, disopyramide, nicainoprol and propranolol all significantly(More)
The electrophysiologic effects of a new anti-arrhythmic agent NE-10064 were compared with known class III drugs, E-4031 and sotalol, in sheep Purkinje fibres paced at 1 Hz under normal and simulated ischaemic conditions. NE-10064 0.3-3 microM and sotalol 0.3-300 microM prolonged action potential duration at 90% of repolarization (APD90) and effective(More)
The increasing complexity of automotive networks has led to broad security issues related to human safety. On the other hand, to solve problems of network overload, the automotive world is moving in the direction of using an Ethernet backbone for in-vehicle communications. Therefore, the security of Ethernet protocols for such applications has become a(More)
The aim of this study was to examine the effects of hypoxia (PO2 = 34 mm Hg), acidosis (pH 6.8), lactate (10 mM), glucose removal, hyperkalaemia (8 mM), and lysophosphatidylcholine (5-50 microM), alone and in combination, on paced sheep Purkinje fibre action potentials in an attempt to find a combination that simulated the electrophysiological changes(More)
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