Diego Garcia Gomez

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Within 3 hours of induction of acute hydrocephalus in a canine model, lateral ventricular CSF pressure increased from an initial average of 14.6 +/- 2.8 cm H2O to 40.2 +/- 5.7 cm H2O. Ventricular volumes, as measured from MR images, increased 1.45 +/- 0.94 cm3, 1.92 +/- 0.82 cm3, and 2.24 +/- 0.60 cm3 after 6, 24, and 48 hours, of hydrocephalus,(More)
The brain of 17 asymptomatic normal adult beagles was evaluated with magnetic resonance imaging. Lateral ventricular size was quantified using computer algorithms. In beagles with large ventricles, contrast medium was introduced into the cerebellomedullary cistern to determine whether obstructive hydrocephalus was present. Total lateral ventricular volume(More)
RATIONALE AND OBJECTIVES A model of chronic noncommunicating hydrocephalus in canines was developed, and gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging, physiologic and morphologic studies were performed to investigate transventricular absorption of cerebrospinal fluid. METHODS Chronic hydrocephalus was induced in 12 mongrel dogs by(More)
Portions of the superior sagittal sinus and lacunae laterales containing arachnoid villi and granulations from 8 full-term newborn babies were studied by transmission electron microscopy. Arachnoid proliferations from 3 subjects were distended and fixed in vitro by applying a differential pressure of 8 cm H2O to the subarachnoid aspect of the tissues. The(More)
Twenty rabbits were intrathecally perfused with horseradish peroxidase (HRP) without increasing the cerebrospinal fluid (CSF) pressure. Histologic and ultrastructural studies of the olfactory nerve and nasal mucosa showed HRP along the space between peri- and epineurium down to the smaller nerve branches in the mucosa. Within the mucosa, HRP leaked out from(More)
The mechanisms of CSF formation and absorption have been reviewed. The conditions that alter the rate of CSF formation and absorption may change the concentration of contrast in the cranial cisterns and the rate of passage through the cisterns. The significance of these alterations in relation to the complications of myelography with water-soluble contrast(More)
Human spinal arachnoid villi and granulations were studied after distension by a subarachnoid perfusion of Berlin blue and trypan blue. These proliferations were distributed on almost every nerve root in the thoracic and lumbar region. Human spinal arachnoid villi and granulations were divided into those located entirely internal to the dura, those that(More)