Diego Fonseca Pereira de Souza

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Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperature-dependent cell morphology change from mycelium (22 degrees C) to yeast (36 degrees C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST(More)
Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine D2 receptors, with a favorable pharmacological profile. Due to its unique mechanism of action, this compound has potential application as a substitutive therapy for drug addiction. Considering that distinct neural systems subserve the addictive and analgesic actions of opioids, we(More)
Proteins from latex of Calotropis procera (CpLP), Plumeria rubra (PrLP), Carica candamarcensis (P1G10) and Euphorbia tirucalli (EtLP) were tested for antifungal activity against phytopathogens. CpLP and P1G10 inhibited each fungi analyzed. PrLP and EtLP did not exert inhibition. CpLP and P1G10 exhibited preferential inhibitory activity towards R. solani(More)
Both preclinical and clinical data have identified leukocyte function-associated antigen-1 (LFA-1) as an important component of inflammatory disease states. We evaluated small molecule inhibitors of this glycoprotein in several animal models in which the inflammatory process is dependent on human or non-human primate LFA-1.(More)
Datasets with a large amount of noisy data are quite common in real-world classification problems. Robustness is an important characteristic of state-of-the-art classifiers that use error minimization techniques, thus requiring a long time to converge. This paper presents ClusWiSARD, a clustering customization of the WiSARD weightless neural network model,(More)
The defensive role of the latex of Calotropis procera has recently been reported. In this study, latex proteins involved in detrimental effects on insects were evaluated on another important crop pest. The latex was fractionated to obtain its major protein fraction, which was then used to evaluate its insecticidal properties against Callosobruchus maculatus(More)
This work proposes a new method, KernelCanvas, that is adequate to the Weightless Neural Model known as WiSARD for generating a fixed length binary input from spatio-temporal patterns. The method, based on kernel distances, is simple to implement and scales linearly to the number of kernels. Five different datasets were used to evaluate its performance in(More)
Studies investigating the resistance–susceptibility of crop insects to proteins found in latex fluids have been reported. However, latex-bearing plants also host insects. In this study, the gut proteolytic system of Pseudosphinx tetrio, which feeds on Plumeria rubra leaves, was characterized and further challenged against the latex proteolytic system of its(More)
Music tracking is a useful technique for many music related tasks. Some applications include evaluating musicians performance, automatic score page turning and syncing music lyrics. In this work, we describe a WiSARD-based system for real-time music tracking and evaluate the performance of the corresponding implementation. Given any audio example, the(More)
This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigated. It was evaluated if the administration of PCS triggers toxic effect. Treatment with PCS(More)