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Some types of epileptic seizures involve both thalamus and cerebral cortex, while other types can be evoked in the cerebral cortex without thalamic participation. We investigated the possible role of low-threshold spike (LTS) cortical neurons in the genesis of these intracortical seizures. We found LTS cortical neurons in cat area 5}7 in vivo, the(More)
Although in the last few decades a variety of theoretical tools have been developed to better understand living organisms, their impact on experimental research has been rather limited. A common element between these theories is the idea of metabolic closure, i.e., the systems that produce all their metabolites and catalysts. In spite of an increasing(More)
To reconstruct synaptic background activity, we combined computational models with intracellular recordings in vivo. A new conductance analysis method applied to intracellular recordings in the somatosensory cortex of anesthetized rats revealed mirror changes of excitation and inhibition during the up-and down-states of slow waves, but concerted changes in(More)
There are deep underlying similarities between Rosen's (M,R) systems as a definition of life and the RAF sets (Reflexive Autocatalytic systems generated by a Food source) introduced by Hordijk and Steel as a way of analyzing autocat-alytic sets of reactions. Using RAF concepts we have systematically explored the set of possible small idealized metabolic(More)
We examine the properties of the transfer function F(T)=V(m)/V(LFP) between the intracellular membrane potential (V(m)) and the local field potential (V(LFP)) in cerebral cortex. We first show theoretically that, in the subthreshold regime, the frequency dependence of the extracellular medium and that of the membrane potential have a clear incidence on(More)
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