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- Cristina Benito, Juan P. Romero, +5 authors Julián Esparza Romero
- The Journal of neuroscience : the official…
- 2007
Increasing evidence supports the idea of a beneficial effect of cannabinoid compounds for the treatment of multiple sclerosis (MS). However, most experimental data come from animal models of MS. We… (More)
- Diego Clemente, Angel Porteros, +4 authors Rosario Arévalo Arévalo
- The Journal of comparative neurology
- 2004
Recently, the zebrafish has been extensively used for studying the development of the central nervous system (CNS). However, the zebrafish CNS has been poorly analyzed in the adult. The… (More)
- Diego Clemente, MarÃa Cristina Ortega, Francisco Javier Arenzana, Fernando de Castro
- The Journal of neuroscience : the official…
- 2011
Multiple sclerosis is a demyelinating disease that affects ≈ 2,000,000 people worldwide. In the advanced stages of the disease, endogenous oligodendrocyte precursors cannot colonize the lesions or… (More)
- Francisco Javier Arenzana, Diego Clemente, Rosario Sánchez-González, Angel Porteros, José Aijón, Rosario Arévalo Arévalo
- Brain Research Bulletin
- 2005
We have analyzed the distribution pattern of choline acetyltransferase (ChAT) in the zebrafish brain and retina during ontogeny. ChAT-immunoreactive (ChAT-ir) neurons are observed in the… (More)
- Verónica Moliné-Velázquez, Henar Cuervo, Virginia Vila-Del Sol, MarÃa Cristina Ortega, Diego Clemente, Fernando de Castro
- Brain pathology
- 2011
Multiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing-remitting MS is characterized by a relapsing phase with clinical symptoms and the production… (More)
- Fabian Docagne, Vilma C. Muñetón, +7 authors Carmen Guaza
- Molecular and Cellular Neuroscience
- 2007
Inflammation, autoimmune response, demyelination and axonal damage are thought to participate in the pathogenesis of multiple sclerosis (MS). Understanding whether axonal damage causes or originates… (More)
- Diego Clemente, MarÃa Cristina Ortega, Carolina Melero-Jerez, Fernando de Castro
- Front. Cell. Neurosci.
- 2013
Oligodendrocyte precursor cells (OPCs) originate in specific areas of the developing central nervous system (CNS). Once generated, they migrate towards their destinations where they differentiate… (More)
- Diego GarcÃa-González, Diego Clemente, Maria Coelho, Pedro F. Esteban, Fernando Comparsi de Castro
- Experimental Neurology
- 2010
FGF-2 and Anosmin-1 are diffusible proteins which act in cell proliferation and/or migration during CNS development. We describe their developmental expression patterns in the subventricular zone… (More)
- Ana Bribián, Pedro F. Esteban, +4 authors Fernando de Castro
- Developmental neurobiology
- 2008
At embryonic stages of development, oligodendrocyte precursors (OPCs) generated in the preoptic area colonize the entire optic nerve (ON). Different factors controlling migration of ON OPCs have been… (More)
- Verónica Moliné-Velázquez, Virginia Vila-Del Sol, Fernando de Castro, Diego Clemente
- Histology and histopathology
- 2016
Multiple sclerosis (MS) is a demyelinating disease in which an exacerbated immune response provokes oligodendrocyte loss and demyelination, the hallmarks of this neurological disease. The destruction… (More)