Diego C. Martínez

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In classical abstract argumentation, arguments interact with each other through a single abstract notion of attack. However, several concrete forms of argument conflict are present in the literature, all of them of different nature and strength for a particular context. In this work we define an argumentation framework equipped with a set of abstract attack(More)
Although the development of an acidic tissue environment or acidosis is a hallmark of inflammatory processes, few studies analyze the effect of extracellular pH on immune cells. We have previously shown that exposure of murine dendritic cells (DCs) to pH 6.5 stimulates macropinocytosis and cross-presentation of extracellular Ags by MHC class I molecules. We(More)
Inflammation in peripheral tissues is usually associated with the development of local acidosis; however, there are few studies aimed at analyzing the influence of acidosis on immune cells. We have shown previously that extracellular acidosis triggers human neutrophil activation, inducing a transient increase in intracellular Ca2+ concentration, a shape(More)
In this work we formalize a natural expansion of timed argumentation frameworks by considering arguments that are available with (possibly) some repeated interruptions in time, called intermittent arguments. This framework is used as a modelization of argumentation dynamics. The notion of acceptability of arguments is analyzed as the framework evolves(More)
We have previously shown that bacterial DNA activates human neutrophils in a CpG-independent manner. In this study, we have characterized the signaling pathways involved in the activation mechanism. We found that p38 MAPK, ERK1/2, and JNK pathways, as well as the PI3K/Akt pathway, are activated by bacterial DNA. We also determined that bacterial DNA induces(More)
Extended abstract frameworks separate conflicts and preference between arguments. These elements are combined to induce argument defeat relations. A proper defeat is consequence of preferring an argument in a conflicting pair, while blocking defeat is consequence of incomparable or equivalent-in-strength conflicting arguments. As arguments interact with(More)
Extended argumentation framework is a formalism where defeat relations are determined by establishing a preference between arguments involved in symmetric conflicts. This process possibly leads to blocking situations, where conflicting arguments are found to be incomparable or equivalent in strength. In this work we introduce new argumentation semantics for(More)
Dose-response curves of the cellular immune response of C58/wm mice to syngeneic line Ib malignant lymphoid cells (Ib cells) were computer analyzed by the PROBT subroutine in the IBM Scientific Subroutine Package. An analysis of the relative immunogenicity of various admixtures of x-irradiated (XIb) and viable Ib cells (VIb) after i.p. injection showed that(More)