Diego A. Ojeda

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The circadian system is responsible for the generation and maintenance of physiological and behavioral rhythms in mammals and allows synchronization with the environment. Different polymorphisms in clock genes have been studied in healthy humans, providing inconsistent results in different populations. In this study, we evaluated the possibility that two(More)
Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population around the world ranges from 6.2 to 32.4%, with a heritability of 38-40%. However, few studies have explored the role of candidate genes in(More)
Polymorphisms in human clock genes have been evaluated as potential factors influencing circadian phenotypes in several populations. There are conflicting results for the association of a VNTR in the PER3 gene and diurnal preference in different studies. The objective of this study was to investigate the association between diurnal preference and daytime(More)
The molecular study of circadian rhythms in humans could be an excellent approach to understand the relation between genes and behavior. It is possible that variations in genes involved in neurotransmission and/or synaptic plasticity, such as catechol-O-methyltransferase (COMT) and serotonin transporter (SLC6A4) could be of particular interest in(More)
BACKGROUND Non-synonymous single nucleotide polymorphisms (nsSNPs) in brain-expressed genes represent interesting candidates for genetic research in neuropsychiatric disorders. PURPOSE To study novel nsSNPs in brain-expressed genes in a sample of Colombian subjects. METHODS We applied an approach based on in silico mining of available genomic data to(More)
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) has been associated with a large number of human diseases and endophenotypes. The aim of this study was to develop a novel cost-effective assay to genotype this polymorphism. The novel assay was based on the combination of allele-specific PCR and high-resolution melting in(More)
Human telomeres are nucleoprotein structures at both ends of linear chromosomes and are fundamental for the maintenance of genomic stability and cellular ageing, and for the adequate functioning of cells in the entire human organism (Castro-Vega et al. 2013; Eitan et al. 2014). Telomere length (TL) is increasingly being used as a genomic marker associated(More)
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