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  • Bastien Mangeat, Priscilla Turelli, Gersende Caron, Marc Friedli, Luc H. Perrin, Didier Trono
  • Biology, Medicine
  • Nature
  • 2003 (First Publication: 1 July 2003)
  • Viral replication usually requires that innate intracellular lines of defence be overcome, a task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) proteinContinue Reading
  • Simon Quenneville, Gaetano Verde, +8 authors Didier Trono
  • Biology, Medicine
  • Molecular cell
  • 2011 (First Publication: 1 November 2011)
  • The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1,Continue Reading
  • Christopher Aiken, Jason A Konner, Nathaniel R. Landau, Marc E. Lenburg, Didier Trono
  • Biology, Medicine
  • Cell
  • 1994 (First Publication: 11 March 1994)
  • CD4 is crucial for antigen-driven helper T cell signaling and is used as receptor by the human immunodeficiency virus (HIV). The HIV early protein Nef causes a loss of CD4 from cell surfaces throughContinue Reading
  • Luigi Naldini, Ulrike Bloemer, Fred H. Gage, Didier Trono, Inder M. Verma
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 15 October 1996)
  • We describe the construction of a safe, replication-defective and efficient lentiviral vector suitable for in vivo gene delivery. The reverse transcription of the vector was found to be aContinue Reading