Didier Hoarau

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Purpose. To develop and evaluate novel long-circulating lipid nanocapsules (LN) designed for tumor delivery of lipophilic drugs. Methods. Nanocapsules were produced by a solvent-free phase inversion process and were coated with polyethylene glycol-distearoylphosphatidylethanolamine conjugate (DSPE-PEG) during preparation or by a post-insertion step. In vivo(More)
The purpose of this study was to evaluate the ability of poly(ethylene glycol)-coated lipid nanocapsules (LN) to deliver the highly potent hydrophobic anticancer drug docetaxel to solid tumors. Docetaxel-loaded nanocapsules (80–120 nm) were produced by a solvent-free phase inversion process and were coated with polyethylene glycol(More)
The development of simple and efficient drug delivery systems for the sustained release of peptides/proteins and low molecular weight hydrophilic molecules is an ongoing challenge. The purpose of this work was to prepare and characterize novel biodegradable in situ-forming implants obtained via the self-assembly of L-alanine derivatives in pharmaceutical(More)
The recent advent of biotechnologies has led to the development of labile macromolecular therapeutic agents that require complex formulations for their efficient administration. This work reports a novel concept for the systemic, sustained delivery of such agents. The proposed approach is based on the spontaneous self-assembly of low-molecular weight(More)
Spherulites are multilamellar vesicles obtained by shearing a lamellar phase of lipids and surfactants. They consist of concentric bilayers of amphiphiles alternating with layers of aqueous medium in which hydrophilic drugs can be sequestered with high yield. To be useful for drug targeting applications, spherulites should be small and long circulating. The(More)
Many potent therapeutic agents possess a high degree of hydrophobicity which can greatly impede their solubilization in aqueous media and thus hamper their oral or parenteral administration. In order to circumvent this limitation, novel drug delivery systems, such as polymeric micelles and lipid-based nanocapsules, are being developed. In general, these(More)
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