Dicken Shiu-Chung Ko

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The effects of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice have been investigated using a versatile procedure for encapsulating doxorubicin inside liposomes. In this procedure, vesicles exhibiting transmembrane pH gradients (acidic inside) were employed to achieve drug trapping(More)
BACKGROUND Lymphatic leak and lymphocele are well-known complications after kidney transplantation. OBJECTIVE To determine the incidence of lymphatic complications in recipients of living donor kidneys. METHODS Among 642 kidney transplants performed between 1999 and 2007, the incidence of lymphatic complications was retrospectively analyzed in(More)
AIM To compare laparoscopic and open living donor nephrectomy, based on the results from a single center during a decade. METHODS This is a retrospective review of all living donor nephrectomies performed at the Massachusetts General Hospital, Harvard Medical School, Boston, between 1/1998 - 12/2009. Overall there were 490 living donors, with 279(More)
BACKGROUND There are over 250 kidney transplant programs in the USA. OBJECTIVE To determine if highly competitive regions, defined as regions with a higher number of transplant centers, will approve and wait-list more end-stage renal disease (ESRD) candidates for transplant despite consistent incidence and prevalence of ESRD nationwide. METHODS ESRD(More)
BACKGROUND Donor safety is the first priority in living donor liver transplantation (LDLT). OBJECTIVE To determine the characteristics and outcome of live liver donors who underwent donor hepatectomy from January, 1997 to May, 2007 at Massachusetts General Hospital. METHODS 30 patients underwent LDLT between January, 1997 and May, 2007 at our(More)
BACKGROUND Hepatitis C (HCV) is the most common indication for liver transplantation in the US. OBJECTIVE Since steroids are the major stimulus of viral replication, we postulated that steroid-free immunosuppression might be a safer approach. METHODS From January 1995 to October 2002, we used steroid plus calcineurin inhibitor (CNI) immunosuppression(More)
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