• Publications
  • Influence
The depolymerization of chitosan: effects on physicochemical and biological properties.
Chitosan has been extensively used as an absorption enhancer for macromolecules and as gene delivery vehicle. Both properties are molecular weight (MW) dependent. Here, we investigate factorsExpand
  • 305
  • 9
Characterization and Body Distribution of β-Elemene Solid Lipid Nanoparticles (SLN)
ABSTRACT Solid lipid nanoparticles (SLN) containing β-elemene, a volatile oil used for the treatment of cancer, were prepared by the method combining probe sonication and membrane extrusion. EffectsExpand
  • 36
  • 3
Intranasal administration of melatonin starch microspheres.
Using melatonin as model drug, starch microspheres for intranasal administration were prepared by an emulsification-crosslinking technique using a uniform design to optimize preparation conditions.Expand
  • 90
  • 2
Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres.
The gastric mucoadhesive properties of aminated gelatin microspheres were evaluated both in vitro and in vivo. The interactions of gelatin, aminated gelatin and microspheres with two kinds ofExpand
  • 75
  • 1
A novel method to prepare highly encapsulated interferon-alpha-2b containing liposomes for intramuscular sustained release.
A novel modified film-hydration-dilution method was employed to prepare highly encapsulated interferon-alpha-2b containing liposomes for intramuscular sustained release. The liposomes produced byExpand
  • 20
  • 1
Pharmacodynamics and potential toxicity of intranasally administered dipyrone.
Dipyrone is a non-narcotic analgesic and antipyretic drug used in both pediatric and adult patients. Dipyrone solution can be used intranasally as an antipyretic agent for infants. However, dipyroneExpand
  • 11
  • 1
Investigations on 5-fluorouracil solid lipid nanoparticles (SLN) prepared by hot homogenization.
The purpose of this study was to investigate the effect of different formulation factors on the properties of solid lipid nanoparticles (SLN) prepared by a hot homogenization method. Using theExpand
  • 13
  • 1
Aminated gelatin as a nasal absorption enhancer for peptide drugs: evaluation of absorption enhancing effect and nasal mucosa perturbation in rats.
This study was carried out to evaluate the potential of aminated gelatin as a nasal absorption enhancer for peptide drugs. The absorption-enhancing effect was investigated in rats using insulin andExpand
  • 41
Species-dependent plasma metabolism of the ester compound daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5).
Daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5) is an ester-containing compound, which was recently synthesized. The objective of this study was to determine the hydrolysis rate of DZ5 inExpand
  • 2
Determination of #beta#-elemene in solid lipid nanoparticles by RP-HPLC
Objective To develop a RP-HPLC method for the determination of β-elemene in solid lipid nanoparticles(SLN) injection.Methods The separation was carried out on Hypersil BDS C(18) ((5 μm),(4.6 mm×)Expand
  • 3