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—Maximum likelihood recursions of Wu can be used to estimate extreme percentiles of a dose-quantal effective curve. For certain choices of initial designs, Wu's method performs well. In bioassay, there often exist some different initial designs which are known as the up-and-down designs. Based on the existing data set from such a design, we propose three(More)
In pharmaceutical analysis, the window that cases effective response with probability larger than p is important and need to be precisely estimated. For this difficult issue, we propose a two-phase design by combining D-optimal strategy and likelihood recursive approximation to estimate it. Simulation study shows that the estimate is accurate and(More)
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