Dianne Murray

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Since the early 1980's, intelligent and adaptive systems have appeared and have been written about in a variety of guises. Although there are many differences between such systems as adaptive user interfaces, intelligent help systems and explanation systems, there are many similarities as well. The most notable of these is that they all require user models(More)
Control of chondrocyte pH (pH(i)) determines articular cartilage matrix metabolism. However, the transporters of chondrocytes in situ throughout cartilage zones are unclear, and we tested the hypothesis that chondocytes within the superficial zone (SZ) utilise a HCO(3) (-)-dependent system absent from other zones. Imaging of single BCECF-labelled cells was(More)
We consider the significant work in both the humancomputer interaction and artificial intelligence fields in the area of intelligent interfaces, placing into a structure the disparate strands of research work. We treat design and implementation issues, covering the relationship between user interface management systems (UIMS) architectures and interface(More)
PURPOSE To evaluate computed tomographic (CT) colonography as a screening tool for average-risk asymptomatic subjects with regard to participation, acceptability, and safety. MATERIALS AND METHODS CT colonography for colorectal neoplasia screening was offered to 2,000 subjects aged 50-54 and 65-69 years. Only asymptomatic subjects at average risk of(More)
Early osteoarthritis (OA) is poorly understood, but abnormal chondrocyte morphology might be important. We studied IL-1β and pericellular collagen type VI in morphologically normal and abnormal chondrocytes. In situ chondrocytes within explants from nondegenerate (grade 0/1) areas of human tibial plateaus (n = 21) were fluorescently labeled and visualized(More)
Bone strength is, in part, dependent on a mechanical input that regulates the (re)modelling of skeletal elements to an appropriate size and architecture to resist fracture during habitual use. The rate of longitudinal bone growth in juveniles can also affect fracture incidence in adulthood, suggesting an influence of growth rate on later bone quality. We(More)